PMID- 12838504
OWN - NLM
STAT- MEDLINE
DCOM- 20031118
LR  - 20190508
IS  - 0894-1491 (Print)
IS  - 0894-1491 (Linking)
VI  - 43
IP  - 2
DP  - 2003 Aug
TI  - Tumor necrosis factor is required for RANTES-induced astrocyte monocyte 
      chemoattractant protein-1 production.
PG  - 119-27
AB  - Astrocytes respond to stimulation with the chemokine RANTES (regulated on 
      activation, normal T cell expressed) by production of a series of cytokines and 
      chemokines, including tumor necrosis factor-alpha (TNF-alpha) and monocyte 
      chemoattractant protein-1 (MCP-1). In the present study we demonstrate that 
      RANTES induces TNF, which in turn stimulates subsequent production of MCP-1. 
      TNF-R1 (p55) serves as the principal receptor responsible for MCP-1 synthesis. 
      The results define an astrocyte proinflammatory cascade that amplifies synthesis 
      of proinflammatory mediators. The implications of these findings to inflammatory 
      diseases of the central nervous system are discussed.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Luo, Yi
AU  - Luo Y
AD  - Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, 
      USA.
FAU - Berman, Michael A
AU  - Berman MA
FAU - Abromson-Leeman, Sara R
AU  - Abromson-Leeman SR
FAU - Dorf, Martin E
AU  - Dorf ME
LA  - eng
GR  - NS042900/NS/NINDS NIH HHS/United States
GR  - R01 CA067416-04/CA/NCI NIH HHS/United States
GR  - R01 NS042900-02/NS/NINDS NIH HHS/United States
GR  - CA67416/CA/NCI NIH HHS/United States
GR  - R01 NS042900/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Antibodies)
RN  - 0 (Antigens, CD)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokine CXCL2)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Monokines)
RN  - 0 (Protein Synthesis Inhibitors)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Antigens, CD/metabolism
MH  - Astrocytes/drug effects/*metabolism
MH  - Cells, Cultured
MH  - Chemokine CCL2/*metabolism
MH  - Chemokine CCL4
MH  - Chemokine CCL5/*physiology
MH  - Chemokine CXCL2
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Immunohistochemistry
MH  - Macrophage Inflammatory Proteins/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Knockout
MH  - Monokines/metabolism
MH  - Nuclease Protection Assays/methods
MH  - Protein Synthesis Inhibitors/pharmacology
MH  - Receptors, Tumor Necrosis Factor/metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/immunology/*physiology
EDAT- 2003/07/03 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/07/03 05:00
PHST- 2003/07/03 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/07/03 05:00 [entrez]
AID - 10.1002/glia.10231 [doi]
PST - ppublish
SO  - Glia. 2003 Aug;43(2):119-27. doi: 10.1002/glia.10231.