PMID- 12842310
OWN - NLM
STAT- MEDLINE
DCOM- 20030822
LR  - 20220408
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 54
IP  - 1
DP  - 2003 Jul 1
TI  - Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in 
      depressed patients with or without antidepressants.
PG  - 70-5
AB  - BACKGROUND: Because researchers have reported that antidepressants increase the 
      expression of brain-derived neurotrophic factor (BDNF) in the rat hippocampus, we 
      investigated whether serum BDNF levels may be used as a putative biological 
      marker for major depressive disorders (MDD). METHODS: We measured serum BDNF in 
      the following three groups: antidepressant-naive patients with MDD (n = 16), 
      antidepressant-treated patients with MDD (n = 17), and normal control subjects (n 
      = 50). Patients were evaluated using the Hamilton Rating Scale for Depression 
      (HAM-D). Serum BDNF was assayed with the sandwich ELISA method. RESULTS: We found 
      that serum BDNF was significantly lower in the antidepressant-naive group (mean, 
      17.6 ng/mL; SD, 9.6) than in the treated (mean, 30.6 ng/mL; SD, 12.3; p =.001) or 
      in the control group (mean, 27.7 ng/mL; SD, 11.4; p =.002). There was a 
      significant negative correlation (r = -.350, z = -2.003, p =.045) between serum 
      BDNF and HAM-D scores in all patients. In a preliminary examination, reduced BDNF 
      values of three drug-naive patients recovered to basal levels after 
      antidepressant treatment. CONCLUSIONS: Our study suggests that low BDNF levels 
      may play a pivotal role in the pathophysiology of MDD and that antidepressants 
      may increase BDNF in depressed patients.
FAU - Shimizu, Eiji
AU  - Shimizu E
AD  - Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, 
      Japan.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
FAU - Okamura, Naoe
AU  - Okamura N
FAU - Koike, Kaori
AU  - Koike K
FAU - Komatsu, Naoya
AU  - Komatsu N
FAU - Kumakiri, Chikara
AU  - Kumakiri C
FAU - Nakazato, Michiko
AU  - Nakazato M
FAU - Watanabe, Hiroyuki
AU  - Watanabe H
FAU - Shinoda, Naoyuki
AU  - Shinoda N
FAU - Okada, Sin-ichi
AU  - Okada S
FAU - Iyo, Masaomi
AU  - Iyo M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Antidepressive Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/pharmacology/*therapeutic use
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood/drug effects
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/*blood/*drug therapy
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2003/07/05 05:00
MHDA- 2003/08/23 05:00
CRDT- 2003/07/05 05:00
PHST- 2003/07/05 05:00 [pubmed]
PHST- 2003/08/23 05:00 [medline]
PHST- 2003/07/05 05:00 [entrez]
AID - S0006322303001811 [pii]
AID - 10.1016/s0006-3223(03)00181-1 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2003 Jul 1;54(1):70-5. doi: 10.1016/s0006-3223(03)00181-1.