PMID- 12843304
OWN - NLM
STAT- MEDLINE
DCOM- 20030912
LR  - 20081121
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 90
IP  - 1
DP  - 2003 Jul
TI  - Relationships between skin temperature and temporal summation of heat and cold 
      pain.
PG  - 100-9
AB  - Temporal summation of heat pain during repetitive stimulation is dependent on C 
      nociceptor activation of central N-methyl-d-aspartate (NMDA) receptor mechanisms. 
      Moderate temporal summation is produced by sequential triangular ramps of 
      stimulation that control skin temperature between heat pulses but do not elicit 
      distinct first and second pain sensations. Dramatic summation of second pain is 
      produced by repeated contact of the skin with a preheated thermode, but skin 
      temperature between taps is not controlled by this procedure. Therefore 
      relationships between recordings of skin temperature and psychophysical ratings 
      of heat pain were evaluated during series of repeated skin contacts. Surface and 
      subcutaneous recordings of skin temperatures revealed efficient thermoregulatory 
      compensation for heat stimulation at interstimulus intervals (ISIs) ranging from 
      2 to 8 s. Temporal summation of heat pain was strongly influenced by the ISIs and 
      cannot be explained by small increases in skin temperature between taps or by 
      heat storage throughout a stimulus series. Repetitive brief contact with a 
      precooled thermode was utilized to evaluate whether temporal summation of cold 
      pain occurs, and if so, whether it is influenced by skin temperature. Surface and 
      subcutaneous recordings of skin temperature revealed a sluggish thermoregulatory 
      compensation for repetitive cold stimulation. In contrast to heat stimulation, 
      skin temperature did not recover between cold stimuli throughout ISIs of 3-8 s. 
      Psychophysically, repetitive cold stimulation produced an aching pain sensation 
      that progressed gradually and radiated beyond the site of stimulation. The 
      magnitude of aching pain was well related to skin temperature and thus appeared 
      to be established primarily by peripheral factors.
FAU - Mauderli, Andre P
AU  - Mauderli AP
AD  - Department of Neuroscience, University of Florida Colleges of Medicine and 
      Dentistry, Gainesville, Florida 21610-0244, USA.
FAU - Vierck, Charles J Jr
AU  - Vierck CJ Jr
FAU - Cannon, Richard L
AU  - Cannon RL
FAU - Rodrigues, Anthony
AU  - Rodrigues A
FAU - Shen, Chiayi
AU  - Shen C
LA  - eng
GR  - NS-43435/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Adult
MH  - *Cold Temperature
MH  - Female
MH  - *Hot Temperature
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain/*physiopathology/*psychology
MH  - Pain Measurement
MH  - Psychophysics
MH  - *Skin Temperature
MH  - Time Factors
EDAT- 2003/07/05 05:00
MHDA- 2003/09/13 05:00
CRDT- 2003/07/05 05:00
PHST- 2003/07/05 05:00 [pubmed]
PHST- 2003/09/13 05:00 [medline]
PHST- 2003/07/05 05:00 [entrez]
AID - 90/1/100 [pii]
AID - 10.1152/jn.01066.2002 [doi]
PST - ppublish
SO  - J Neurophysiol. 2003 Jul;90(1):100-9. doi: 10.1152/jn.01066.2002.