PMID- 12845427
OWN - NLM
STAT- MEDLINE
DCOM- 20050425
LR  - 20240209
IS  - 0342-4642 (Print)
IS  - 0342-4642 (Linking)
VI  - 29
IP  - 8
DP  - 2003 Aug
TI  - Correlation between neurotrophic factor expression and outcome of children with 
      severe traumatic brain injury.
PG  - 1329-38
AB  - OBJECTIVES: We evaluated the neurotrophic factors [nerve growth factor (NGF), 
      brain-derived neurotrophic factor (BDNF), glia-derived neurotrophic factor 
      (GDNF)] expression and their association with the severity and outcome of 
      children with traumatic brain injury. DESIGN: Prospective observational clinical 
      study. SETTING: Pediatric intensive care unit. PATIENTS: Fourteen children with 
      severe head injury; 12 controls with obstructive hydrocephalus. MEASUREMENT: 
      Cerebrospinal fluid (CSF) and plasma samples were collected 2 h (T1) and 24 h 
      (T2) after head injury. Neurotrophic factor levels were measured using an 
      immuno-enzymatic assay. MAIN RESULTS: In patients, neurotrophic factor mean 
      levels were significantly different in both CSF and plasma, showing high levels 
      of BDNF compared to NGF and GDNF. Considering T1 and T2 expression, in the CSF 
      the level of NGF increased from 3.5+/-0.4 pg/ml to 48.2+/-11.7 pg/ml ( p<0.001); 
      BDNF decreased from 4854.0+/-1303.7 pg/ml to 593.0+/-114.8 pg/ml ( p<0.001), 
      while GDNF did not undergo significant variations. In plasma, no significant 
      changes were observed. Regarding severity and outcome, BDNF levels showed a sharp 
      peak after head injury, but the only significant association was between NGF 
      expression in the CSF and a good outcome versus a poor outcome ( p=0.007). 
      CONCLUSIONS: The variations in neurotrophic factor levels reflect an endogenous 
      attempt at neuroprotection against biochemical and molecular changes after 
      traumatic head injury. BDNF represents an early marker of brain injury, while NGF 
      expression in the CSF was indicative of a good outcome and the role of this 
      neurotrophin in the treatment of children with severe head injury may be 
      hypothesized.
FAU - Chiaretti, Antonio
AU  - Chiaretti A
AD  - Pediatric Intensive Care Unit, Catholic University Medical School, Policlinico 
      Gemelli, Largo Gemelli, 1-00168, Rome, Italy. achiaretti@yahoo.it
FAU - Piastra, Marco
AU  - Piastra M
FAU - Polidori, Giancarlo
AU  - Polidori G
FAU - Di Rocco, Concezio
AU  - Di Rocco C
FAU - Caresta, Elena
AU  - Caresta E
FAU - Antonelli, Alessia
AU  - Antonelli A
FAU - Amendola, Tiziana
AU  - Amendola T
FAU - Aloe, Luigi
AU  - Aloe L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030705
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GDNF protein, human)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adolescent
MH  - Brain Injuries/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/blood/cerebrospinal fluid
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Humans
MH  - Infant
MH  - Male
MH  - Nerve Growth Factor/blood/cerebrospinal fluid
MH  - Nerve Growth Factors/*blood/*cerebrospinal fluid
MH  - Prognosis
EDAT- 2003/07/08 05:00
MHDA- 2005/04/26 09:00
CRDT- 2003/07/08 05:00
PHST- 2002/06/21 00:00 [received]
PHST- 2003/05/15 00:00 [accepted]
PHST- 2003/07/08 05:00 [pubmed]
PHST- 2005/04/26 09:00 [medline]
PHST- 2003/07/08 05:00 [entrez]
AID - 10.1007/s00134-003-1852-6 [doi]
PST - ppublish
SO  - Intensive Care Med. 2003 Aug;29(8):1329-38. doi: 10.1007/s00134-003-1852-6. Epub 
      2003 Jul 5.