PMID- 12846268
OWN - NLM
STAT- MEDLINE
DCOM- 20031023
LR  - 20190922
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 35
IP  - 4
DP  - 2003
TI  - Use of beta-blockers in congestive heart failure.
PG  - 259-66
AB  - While beta-adrenergic blockers have been used for decades in a variety of 
      cardiovascular illnesses, they have traditionally been avoided in chronic heart 
      failure. In spite of significant advances in management, mortality in patients 
      suffering from heart failure remains unacceptably high and new therapies are 
      urgently needed. Recently, several large clinical trials have shown a significant 
      reduction in both morbidity and mortality in heart failure patients when 
      beta-blockers are added to standard therapy. While further investigation is 
      warranted in certain subgroups, the use of beta-adrenergic blockers in New York 
      Heart Association (NYHA) class II to IV heart failure should now be considered 
      routine. The purpose of this article is to outline and review the five major 
      clinical trials of beta-blocker therapy in chronic heart failure; the US 
      Carvedilol heart failure Program (USCP), the Cardiac Insufficiency Bisoprolol 
      Study II (CIBIS-II), the Metoprolol CR/XL Randomized Intervention Trial in 
      chronic Heart Failure (MERIT-HF), the Beta-blocker Evaluation of Survival Trial 
      (BEST) and the Carvedilol Prospective Randomized Cumulative Survival trial 
      (COPERNICUS), and to aid the reader in the selection of appropriate candidates 
      for beta-blocker therapy.
FAU - Sallach, John A
AU  - Sallach JA
AD  - Cleveland Clinic Foundation, Cleveland, OH, USA. jsallach@yahoo.com
FAU - Goldstein, Sidney
AU  - Goldstein S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Carbazoles)
RN  - 0 (Propanolamines)
RN  - 0K47UL67F2 (Carvedilol)
RN  - GEB06NHM23 (Metoprolol)
RN  - Y41JS2NL6U (Bisoprolol)
SB  - IM
MH  - Adrenergic beta-Antagonists/administration & dosage/*therapeutic use
MH  - Bisoprolol/administration & dosage/therapeutic use
MH  - Carbazoles/administration & dosage/therapeutic use
MH  - Carvedilol
MH  - Dose-Response Relationship, Drug
MH  - Forecasting
MH  - Heart Failure/*drug therapy
MH  - Humans
MH  - Metoprolol/administration & dosage/therapeutic use
MH  - Propanolamines/administration & dosage/therapeutic use
MH  - Randomized Controlled Trials as Topic
RF  - 25
EDAT- 2003/07/09 05:00
MHDA- 2003/10/24 05:00
CRDT- 2003/07/09 05:00
PHST- 2003/07/09 05:00 [pubmed]
PHST- 2003/10/24 05:00 [medline]
PHST- 2003/07/09 05:00 [entrez]
AID - 10.1080/14734220310011716 [doi]
PST - ppublish
SO  - Ann Med. 2003;35(4):259-66. doi: 10.1080/14734220310011716.