PMID- 12847275
OWN - NLM
STAT- MEDLINE
DCOM- 20031023
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 171
IP  - 2
DP  - 2003 Jul 15
TI  - Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways 
      is a critical step in a mouse model of asthma.
PG  - 1016-22
AB  - Dendritic cells (DCs) appear to be strategically implicated in allergic diseases, 
      including asthma. Matrix metalloproteinase (MMP)-9 mediates transmigration of 
      inflammatory leukocytes across basement membranes. This study investigated the 
      role of MMP-9 in airway DC trafficking during allergen-induced airway 
      inflammation. MMP-9 gene deletion affected the trafficking of pulmonary DCs in a 
      specific way: only the inflammatory transmigration of DCs into the airway lumen 
      was impaired, whereas DC-mediated transport of airway Ag to the thoracic lymph 
      nodes remained unaffected. In parallel, the local production of the 
      Th2-attracting chemokine CC chemokine ligand 17/thymus and activation-regulated 
      chemokine, which was highly concentrated in purified lung DCs, fell short in the 
      airways of allergen-exposed MMP-9(-/-) mice. This was accompanied by markedly 
      reduced peribronchial eosinophilic infiltrates and impaired allergen-specific IgE 
      production. We conclude that the specific absence of MMP-9 activity inhibits the 
      development of allergic airway inflammation by impairing the recruitment of DCs 
      into the airways and the local production of DC-derived proallergic chemokines.
FAU - Vermaelen, Karim Y
AU  - Vermaelen KY
AD  - Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium. 
      Karim.Vermaelen@rug.ac.be
FAU - Cataldo, Didier
AU  - Cataldo D
FAU - Tournoy, Kurt
AU  - Tournoy K
FAU - Maes, Tania
AU  - Maes T
FAU - Dhulst, An
AU  - Dhulst A
FAU - Louis, Renaud
AU  - Louis R
FAU - Foidart, Jean-Michel
AU  - Foidart JM
FAU - Noel, Agnes
AU  - Noel A
FAU - Pauwels, Romain
AU  - Pauwels R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Allergens)
RN  - 0 (Ccl17 protein, mouse)
RN  - 0 (Ccl22 protein, mouse)
RN  - 0 (Chemokine CCL17)
RN  - 0 (Chemokine CCL22)
RN  - 0 (Chemokines, CC)
RN  - 9006-59-1 (Ovalbumin)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Allergens/administration & dosage
MH  - Animals
MH  - Asthma/enzymology/genetics/*immunology/*pathology
MH  - Cell Differentiation/genetics/immunology
MH  - Cell Movement/*immunology
MH  - Cells, Cultured
MH  - Chemokine CCL17
MH  - Chemokine CCL22
MH  - Chemokines, CC/biosynthesis
MH  - Dendritic Cells/enzymology/*immunology/metabolism/*pathology
MH  - Disease Models, Animal
MH  - Female
MH  - Inflammation/enzymology/genetics/pathology/prevention & control
MH  - Lung/enzymology/*immunology/metabolism/*pathology
MH  - Lymph Nodes/immunology/pathology
MH  - Male
MH  - Matrix Metalloproteinase 9/deficiency/genetics/*physiology
MH  - Mediastinum
MH  - Mice
MH  - Mice, Knockout
MH  - Ovalbumin/administration & dosage/immunology
MH  - Respiratory Mucosa/enzymology/immunology/pathology
EDAT- 2003/07/09 05:00
MHDA- 2003/10/24 05:00
CRDT- 2003/07/09 05:00
PHST- 2003/07/09 05:00 [pubmed]
PHST- 2003/10/24 05:00 [medline]
PHST- 2003/07/09 05:00 [entrez]
AID - 10.4049/jimmunol.171.2.1016 [doi]
PST - ppublish
SO  - J Immunol. 2003 Jul 15;171(2):1016-22. doi: 10.4049/jimmunol.171.2.1016.