PMID- 12847405
OWN - NLM
STAT- MEDLINE
DCOM- 20030812
LR  - 20171116
IS  - 0090-3493 (Print)
IS  - 0090-3493 (Linking)
VI  - 31
IP  - 7
DP  - 2003 Jul
TI  - Marked elevation of human circulating CD4+CD25+ regulatory T cells in 
      sepsis-induced immunoparalysis.
PG  - 2068-71
AB  - OBJECTIVE: Immunoparalysis has recently emerged as a possible cause explaining 
      the failure of clinical trials in septic shock. Because human peripheral blood 
      CD4+CD25+ T cells have been characterized as suppressor T cells, we hypothesized 
      they might be increased in sepsis-induced immunoparalysis. DESIGN: Prospective, 
      observational, clinical study. SETTING: Adult intensive care units in a 
      university hospital. SUBJECTS: Patients with septic shock (n = 16) and healthy 
      individuals (n = 36). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: In 
      patients with septic shock (mortality rate at 28 days, 56%; mean admission 
      Simplified Acute Physiology Score II, 47), we first illustrated immunoparalysis 
      by showing a severe diminished monocytic human leukocyte antigen (HLA)-DR 
      expression. Afterward, compared with control values, we found in these patients a 
      marked elevation of circulating CD4+CD25+ T cells that were also CD45RO+ and 
      CD69- and overexpressed CTLA-4. Importantly, nonsurvivors (n = 9) presented 
      prolonged lower monocytic HLA-DR expression and higher percentage of CD4+CD25+ 
      T-suppressor T cells. CONCLUSIONS: These data support the concept that the 
      persistence of a pronounced immunoparalysis after septic shock is associated with 
      a poor outcome. Whether CD4+CD25+ T cells directly participate in sepsis-induced 
      immunoparalysis remains to be investigated.
FAU - Monneret, Guillaume
AU  - Monneret G
AD  - Lyon-Sud University Hospital, France. guillaume.monneret@chu-lyon.fr
FAU - Debard, Anne-Lise
AU  - Debard AL
FAU - Venet, Fabienne
AU  - Venet F
FAU - Bohe, Julien
AU  - Bohe J
FAU - Hequet, Olivier
AU  - Hequet O
FAU - Bienvenu, Jacques
AU  - Bienvenu J
FAU - Lepape, Alain
AU  - Lepape A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD69 antigen)
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (CTLA4 protein, human)
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Immunoconjugates)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Interleukin-2)
RN  - 7D0YB67S97 (Abatacept)
RN  - EC 3.1.3.48 (Leukocyte Common Antigens)
SB  - IM
CIN - Crit Care Med. 2005 Mar;33(3):700; author reply 700-1. PMID: 15753784
MH  - Abatacept
MH  - Antigens, CD/blood
MH  - Antigens, Differentiation/blood
MH  - Antigens, Differentiation, T-Lymphocyte/blood
MH  - CD4 Antigens/*blood
MH  - CTLA-4 Antigen
MH  - *Critical Care
MH  - Cytokines/*blood
MH  - Female
MH  - Flow Cytometry
MH  - HLA-DR Antigens/blood
MH  - Hospital Mortality
MH  - Humans
MH  - Immune Tolerance/*immunology
MH  - *Immunoconjugates
MH  - Lectins, C-Type
MH  - Leukocyte Common Antigens/blood
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Monocytes/immunology
MH  - Prognosis
MH  - Receptors, Interleukin-2/*blood
MH  - Shock, Septic/*immunology/mortality
MH  - Survival Rate
MH  - T-Lymphocytes/*immunology
MH  - T-Lymphocytes, Regulatory/*immunology
EDAT- 2003/07/09 05:00
MHDA- 2003/08/13 05:00
CRDT- 2003/07/09 05:00
PHST- 2003/07/09 05:00 [pubmed]
PHST- 2003/08/13 05:00 [medline]
PHST- 2003/07/09 05:00 [entrez]
AID - 10.1097/01.CCM.0000069345.78884.0F [doi]
PST - ppublish
SO  - Crit Care Med. 2003 Jul;31(7):2068-71. doi: 10.1097/01.CCM.0000069345.78884.0F.