PMID- 12848305
OWN - NLM
STAT- MEDLINE
DCOM- 20031218
LR  - 20041117
IS  - 0394-3402 (Print)
IS  - 0394-3402 (Linking)
VI  - 16
IP  - 1
DP  - 2003 Feb
TI  - Prevalence of carotid stenosis in type 2 diabetic patients asymptomatic for 
      cerebrovascular disease.
PG  - 48-55
AB  - Stroke, with an incidence of 2.5 x 10(3) yr(-1) (95% CI, 2.3-2.8 x 10(3) yr(-1)), 
      is the third most frequent cause of death and the first cause of disability in 
      western society. Diabetes is an important risk factor for ischaemic stroke, 
      second only to hypertension, whereas it does not seem to be associated with an 
      increased risk of haemorrhagic stroke. The incidence of stroke in men and women 
      between 45 and 74 yr has been found to be 2.5 and 3.5 times higher in diabetics 
      than in non-diabetic subjects, with a relative risk higher in females than in 
      males with diabetes and greater in both sexes in the 50-to-60-yr age group but 
      decreased in subjects who were 70 and above. It is known that there is an 
      association between ischaemic stroke and carotid stenosis. However, the 
      prevalence of carotid stenosis in Type 2 diabetes mellitus (T2DM) patients has 
      not been well investigated, mainly in the Italian diabetic population. Therefore, 
      the aim of this study was to evaluate the prevalence of carotid artery stenosis 
      in a population of T2DM patients asymptomatic for cerebrovascular disease 
      selected from the files of the Diabetes Clinics, and from the computerised files 
      of General Practitioners (GPs). Three hundred and sixty-five subjects were 
      examined: 187 were non-diabetic (89 males, 98 females) and 178 were T2DM patients 
      (82 males, 96 females). The mean age of all the subjects was 67 +/- 7.8 yr; 66 
      +/- 7.9 for the non-diabetic subjects and 67 +/- 7.5 yr in the diabetic subjects. 
      In the echo-Doppler examination of the carotid, a degree of stenosis ranging 
      10-99% was recorded in 143/365 subjects (39.1%), 49/187 non-diabetics (26.2%) and 
      94/178 diabetics (52.8%). The differences were highly significant (p < 0.001). 
      Severe stenosis was recorded in 17/143 subjects (12%); 12 of these were diabetic 
      (70%) and 5 non-diabetic (30%). The diabetics were three times more likely to 
      develop carotid stenosis than the non-diabetics with an odds ratio of 3.152, (95% 
      CI, 2.032-4.889).
FAU - De Angelis, M
AU  - De Angelis M
AD  - Department of Internal Medicine, University of Perugia, Italy. maxdeang@unipg.it
FAU - Scrucca, L
AU  - Scrucca L
FAU - Leandri, M
AU  - Leandri M
FAU - Mincigrucci, S
AU  - Mincigrucci S
FAU - Bistoni, S
AU  - Bistoni S
FAU - Bovi, M
AU  - Bovi M
FAU - Calabrese, G
AU  - Calabrese G
FAU - Pippi, R
AU  - Pippi R
FAU - Parretti, D
AU  - Parretti D
FAU - Grilli, P
AU  - Grilli P
FAU - Colorio, P
AU  - Colorio P
FAU - Fattorini, M
AU  - Fattorini M
FAU - Flamini, O
AU  - Flamini O
FAU - Pacetti, E
AU  - Pacetti E
FAU - Travaglini, A
AU  - Travaglini A
FAU - Santeusanio, F
AU  - Santeusanio F
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Diabetes Nutr Metab
JT  - Diabetes, nutrition & metabolism
JID - 8813443
SB  - IM
MH  - Aged
MH  - Carotid Stenosis/*epidemiology/etiology
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Echocardiography, Doppler
MH  - Female
MH  - Humans
MH  - Italy/epidemiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Prevalence
MH  - Risk Factors
EDAT- 2003/07/10 05:00
MHDA- 2003/12/19 05:00
CRDT- 2003/07/10 05:00
PHST- 2003/07/10 05:00 [pubmed]
PHST- 2003/12/19 05:00 [medline]
PHST- 2003/07/10 05:00 [entrez]
PST - ppublish
SO  - Diabetes Nutr Metab. 2003 Feb;16(1):48-55.