PMID- 12850222
OWN - NLM
STAT- MEDLINE
DCOM- 20030902
LR  - 20190922
IS  - 0959-4388 (Print)
IS  - 0959-4388 (Linking)
VI  - 13
IP  - 3
DP  - 2003 Jun
TI  - Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium 
      signalling and BDNF gene regulation.
PG  - 366-71
AB  - Neuronal responses to electrical activity-induced calcium signals are specified 
      by the localization of the calcium entry site and the spatial properties of the 
      calcium transient. Calcium flux through NMDA receptors located in the synapse 
      initiates changes in synaptic efficacy and promotes pro-survival events, whereas 
      calcium flux through extrasynaptic NMDA receptors is coupled to cell death 
      pathways. The dialogue between the synaptic NMDA receptors and the nucleus is 
      also modulated by extrasynaptic NMDA receptors, which shut down activity of 
      CRE-binding protein (CREB) and antagonize the increase in brain-derived 
      neurotrophic factor (BDNF) expression induced by synaptic NMDA receptors. The 
      specification of the biological response by the localization of the receptor 
      activated is a new concept in neuronal calcium signalling that can explain many 
      of the opposing roles of NMDA receptors.
FAU - Vanhoutte, Peter
AU  - Vanhoutte P
AD  - Signalisation Neuronale et Regulations Geniques, CNRS/UPMC, UMR 7102 9, Paris, 
      France.
FAU - Bading, Hilmar
AU  - Bading H
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Neurobiol
JT  - Current opinion in neurobiology
JID - 9111376
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Calcium Signaling/*physiology
MH  - Extracellular Space/metabolism
MH  - Gene Expression Regulation/physiology
MH  - Humans
MH  - Neurons/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Synapses/*metabolism
RF  - 50
EDAT- 2003/07/10 05:00
MHDA- 2003/09/03 05:00
CRDT- 2003/07/10 05:00
PHST- 2003/07/10 05:00 [pubmed]
PHST- 2003/09/03 05:00 [medline]
PHST- 2003/07/10 05:00 [entrez]
AID - S0959438803000734 [pii]
AID - 10.1016/s0959-4388(03)00073-4 [doi]
PST - ppublish
SO  - Curr Opin Neurobiol. 2003 Jun;13(3):366-71. doi: 10.1016/s0959-4388(03)00073-4.