PMID- 12850371
OWN - NLM
STAT- MEDLINE
DCOM- 20030812
LR  - 20220309
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 144
IP  - 2
DP  - 2003 Jul 15
TI  - Cytogenetic study of malignant triton tumor: a case report.
PG  - 100-5
AB  - Malignant triton tumor (MTT) is a highly malignant neoplasm, classified as a 
      variant of malignant peripheral nerve sheath tumor (MPNST) with rhabdomyoblastic 
      differentiation. Few cytogenetic studies of MTT have been reported using 
      conventional cytogenetic analysis. Here, we report a comprehensive cytogenetic 
      study of a case of MTT using G-banding, Spectral Karyotyping(), and fluorescence 
      in situ hybridization (FISH) for specific regions. A complex hyperdiploid 
      karyotype with multiple unbalanced translocations was observed: 48 approximately 
      55,XY,der(7)add(7)(p?)dup(7)[2],der(7) 
      t(7;20)(p22;?)ins(20;19)[5],der(7)ins(8;7)(?;p22q36)t(3;8)t(8;20)[15],-8[5],-8[19],r(8)dup(8), 
      +der(8)r(8;22)[4],-9[9],der(11)t(11;20)(p15;?)ins(20;19)[22],der(12)t(8;12)(q21;p13)[21],der(13) 
      t(3;13)(q25;p11),-17,-19,der(19)t(17;19)(q11.2;q13.1),-20,-22,+4 approximately 
      7r[cp24]/46,XY[13]. The 1995 International System for Human Cytogenetic 
      Nomenclature was followed where possible. Note that breakpoints were frequently 
      omitted where only SKY information was known for a small part of an involved 
      chromosome. Our analysis revealed some breakpoints in common with those 
      previously reported in MTT, MPNST, and rhabdomyosarcoma, namely 7p22, 7q36, 
      11p15, 12p13, 13p11.2, 17q11.2, and 19q13.1. FISH showed high increase of copy 
      number for MYC and loss of a single copy for TP53.
FAU - Haddadin, Mary H
AU  - Haddadin MH
AD  - Departments of Pathology and Oncology, The Johns Hopkins University School of 
      Medicine, 600 N. Wolfe Street Carnegie 367, Baltimore MD 21287, USA.
FAU - Hawkins, Anita L
AU  - Hawkins AL
FAU - Long, Patricia
AU  - Long P
FAU - Morsberger, Laura A
AU  - Morsberger LA
FAU - Depew, Dawn
AU  - Depew D
FAU - Epstein, Jonathan I
AU  - Epstein JI
FAU - Griffin, Constance A
AU  - Griffin CA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Genes, p53
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Nerve Sheath Neoplasms/*genetics
EDAT- 2003/07/10 05:00
MHDA- 2003/08/13 05:00
CRDT- 2003/07/10 05:00
PHST- 2003/07/10 05:00 [pubmed]
PHST- 2003/08/13 05:00 [medline]
PHST- 2003/07/10 05:00 [entrez]
AID - S0165460802009354 [pii]
AID - 10.1016/s0165-4608(02)00935-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2003 Jul 15;144(2):100-5. doi: 
      10.1016/s0165-4608(02)00935-4.