PMID- 12850425
OWN - NLM
STAT- MEDLINE
DCOM- 20030829
LR  - 20091119
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 26
IP  - 7
DP  - 2003 Jul
TI  - Molecular dissection of neuromuscular junction formation.
PG  - 335-7
AB  - The muscle-specific kinase (MuSK) is the key component that mediates the 
      synapse-inducing role of motoneuron-derived agrin at the neuromuscular junction. 
      Recent reverse-genetics approaches have shed new light on the events triggered 
      inside myotubes by activation of this kinase. Mice in which most of the 
      intracellular domain of MuSK is replaced by a related kinase are viable. Analysis 
      of the imperfect postsynaptic specializations of these mice has provided new 
      insights into the complex postsynaptic differentiation process.
FAU - Hoch, Werner
AU  - Hoch W
AD  - University of Houston, Science and Research Building 2, Houston, TX 77204-5001, 
      USA. whoch@uh.edu
LA  - eng
PT  - Comment
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (Agrin)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
CON - EMBO J. 2000 Jan 4;19(1):67-77. PMID: 10619845
MH  - Agrin/*metabolism
MH  - Animals
MH  - Motor Neurons/metabolism
MH  - Muscle Fibers, Skeletal/*metabolism
MH  - Muscle, Skeletal/*growth & development/metabolism
MH  - Neuromuscular Junction/*growth & development/metabolism
MH  - Receptor Protein-Tyrosine Kinases/*metabolism
MH  - Receptors, Cholinergic/*metabolism
RF  - 14
EDAT- 2003/07/10 05:00
MHDA- 2003/08/30 05:00
CRDT- 2003/07/10 05:00
PHST- 2003/07/10 05:00 [pubmed]
PHST- 2003/08/30 05:00 [medline]
PHST- 2003/07/10 05:00 [entrez]
AID - S0166-2236(03)00131-0 [pii]
AID - 10.1016/S0166-2236(03)00131-0 [doi]
PST - ppublish
SO  - Trends Neurosci. 2003 Jul;26(7):335-7. doi: 10.1016/S0166-2236(03)00131-0.