PMID- 12850818
OWN - NLM
STAT- MEDLINE
DCOM- 20030808
LR  - 20091103
IS  - 1024-5332 (Print)
IS  - 1024-5332 (Linking)
VI  - 7
IP  - 5
DP  - 2002 Oct
TI  - Similarity between hepatic graft-versus-host disease and primary biliary 
      cirrhosis.
PG  - 305-10
AB  - Similarities between hepatic graft-versus-host disease (GVHD) and primary biliary 
      cirrhosis (PBC) have been reported recently. To examine this association, we 
      studied 60 patients who underwent allogeneic bone marrow transplantation (BMT) 
      consecutively at a single medical institution.Among the 60 patients, 12 developed 
      hepatic GVHD after BMT and 48 did not. These two groups were compared with 
      respect to various characteristics seen in PBC, such as autoantibodies, human 
      leukocyte antigen (HLA) status, infection and inflammatory cytokines. The two 
      groups showed a significant difference in HLA DR status. There was also a 
      significant difference in the febrile period and in cytokine levels between the 
      patients with hepatic GVHD and 12 other patients who had no complications after 
      transplantation. These findings suggest that hepatic GVHD resembles PBC and that 
      HLA DR features of PBC may also be risk factors for the onset of hepatic GVHD.
FAU - Wakae, Takeshi
AU  - Wakae T
AD  - Division of Hematology and Oncology, Department of Internal Medicine, Hyogo 
      College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
FAU - Takatsuka, Hiroyuki
AU  - Takatsuka H
FAU - Seto, Yoshifumi
AU  - Seto Y
FAU - Iwata, Nobuo
AU  - Iwata N
FAU - Mori, Ako
AU  - Mori A
FAU - Okada, Masaya
AU  - Okada M
FAU - Fujimori, Yoshihiro
AU  - Fujimori Y
FAU - Okamoto, Takahiro
AU  - Okamoto T
FAU - Kakishita, Eizo
AU  - Kakishita E
FAU - Hara, Hiroshi
AU  - Hara H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Hematology
JT  - Hematology (Amsterdam, Netherlands)
JID - 9708388
RN  - 0 (Autoantibodies)
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Autoantibodies/blood
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Case-Control Studies
MH  - Cytokines/blood
MH  - Female
MH  - Fever
MH  - Graft vs Host Disease/blood/*etiology
MH  - HLA-DR Antigens/blood
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-6/blood
MH  - Liver Cirrhosis, Biliary/blood
MH  - Liver Diseases/blood/*etiology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Transplantation, Homologous/adverse effects
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 2003/07/10 05:00
MHDA- 2003/08/09 05:00
CRDT- 2003/07/10 05:00
PHST- 2003/07/10 05:00 [pubmed]
PHST- 2003/08/09 05:00 [medline]
PHST- 2003/07/10 05:00 [entrez]
AID - PKXCBBQ2P6JU2C6Y [pii]
AID - 10.1080/1024533021000037171 [doi]
PST - ppublish
SO  - Hematology. 2002 Oct;7(5):305-10. doi: 10.1080/1024533021000037171.