PMID- 12851644
OWN - NLM
STAT- MEDLINE
DCOM- 20031106
LR  - 20071115
IS  - 1073-9688 (Print)
IS  - 1073-9688 (Linking)
VI  - 10
IP  - 3-4
DP  - 2003 Jun
TI  - Chemokine receptors in vascular smooth muscle.
PG  - 265-72
AB  - Atherosclerosis is considered to be an inflammatory disease. Chemokines are 
      low-molecular-weight proteins that exert their effects, in part, through 
      mediating leukocytic infiltration into the vessel wall. Recently, studies have 
      determined that chemokines and their receptors are present, and function on other 
      cellular components comprising the arterial wall, such as the endothelium and 
      vascular smooth muscle. Smooth muscle cells (SMC) constitute the major cellular 
      element of the arterial wall and are located predominantly in the arterial media. 
      Recent studies have demonstrated that SMC possess a number of functional 
      chemokine receptors, including CCR5, CXCR4, and a receptor for monocyte 
      chemoattractant protein-1 (MCP-1). It is likely that SMC are increasingly 
      recognized as potential targets for chemokines, and that these effects may 
      influence a variety of normal and pathological processes involving SMC such as 
      atherosclerosis and arterial injury.
FAU - Schecter, Alison D
AU  - Schecter AD
AD  - The Zena and Michael A. Wiener Cardiovascular Institute, New York, NY 14642, USA. 
      alison.shecter@mssm.edu
FAU - Berman, Adriane B
AU  - Berman AB
FAU - Taubman, Mark B
AU  - Taubman MB
LA  - eng
GR  - HL03801/HL/NHLBI NIH HHS/United States
GR  - HL29019/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Microcirculation
JT  - Microcirculation (New York, N.Y. : 1994)
JID - 9434935
RN  - 0 (CCR2 protein, human)
RN  - 0 (CCR4 protein, human)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, CCR4)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Animals
MH  - HIV/physiology
MH  - Humans
MH  - Muscle, Smooth, Vascular/*metabolism/virology
MH  - Receptors, CCR2
MH  - Receptors, CCR4
MH  - Receptors, CCR5/metabolism
MH  - Receptors, Chemokine/*metabolism
MH  - Receptors, Virus/physiology
RF  - 72
EDAT- 2003/07/10 05:00
MHDA- 2003/11/07 05:00
CRDT- 2003/07/10 05:00
PHST- 2002/09/27 00:00 [received]
PHST- 2003/02/01 00:00 [accepted]
PHST- 2003/07/10 05:00 [pubmed]
PHST- 2003/11/07 05:00 [medline]
PHST- 2003/07/10 05:00 [entrez]
AID - 7800192 [pii]
AID - 10.1038/sj.mn.7800192 [doi]
PST - ppublish
SO  - Microcirculation. 2003 Jun;10(3-4):265-72. doi: 10.1038/sj.mn.7800192.