PMID- 12851646
OWN - NLM
STAT- MEDLINE
DCOM- 20031106
LR  - 20220311
IS  - 1073-9688 (Print)
IS  - 1073-9688 (Linking)
VI  - 10
IP  - 3-4
DP  - 2003 Jun
TI  - Arrest chemokines.
PG  - 289-95
AB  - In most organs, leukocyte attachment to the endothelium of blood vessels requires 
      capture and rolling before firm adhesion is initiated by integrin activation 
      and/or redistribution, which can be initiated by immobilized chemokines binding 
      their cognate receptors on rolling cells. Such arrest chemokines are present on 
      the endothelial surface under physiologic or pathologic conditions, necessary, 
      and sufficient to trigger arrest. Although many chemokines can be immobilized and 
      cause arrest of rolling cells in flow chambers, only four have so far been shown 
      to function as arrest chemokines under physiologic conditions, although the 
      actual number could be much higher. Secondary lymphoid tissue chemokine (SLC) 
      (CCL21) on high endothelial venules triggers arrest of rolling lymphocytes, and 
      keratinocyte-derived chemokine (KC) (mouse Gro-alpha, CXCL1), monocyte 
      chemoattractant protein-1 (MCP-1) (CCL2), and regulated on activation, normal T 
      cell exposed and secreted (RANTES) (CCL5) trigger arrest of rolling monocytes. 
      Remarkably, no arrest chemokine for neutrophils under inflammatory conditions has 
      been found so far.
FAU - Ley, Klaus
AU  - Ley K
AD  - Cardiovascular Research Center and Department of Biomedical Engineering 
      University of Virginia Health System, Charlottesville, VA 22903, USA. 
      klausley@virginia.edu
LA  - eng
GR  - HL54136/HL/NHLBI NIH HHS/United States
GR  - HL55798/HL/NHLBI NIH HHS/United States
GR  - HL58108/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Microcirculation
JT  - Microcirculation (New York, N.Y. : 1994)
JID - 9434935
RN  - 0 (Chemokines)
RN  - 0 (Integrins)
SB  - IM
MH  - Animals
MH  - Chemokines/*physiology
MH  - Humans
MH  - Integrins/physiology
MH  - Intracellular Membranes/metabolism
MH  - Leukocyte Rolling/*physiology
MH  - Signal Transduction/physiology
RF  - 51
EDAT- 2003/07/10 05:00
MHDA- 2003/11/07 05:00
CRDT- 2003/07/10 05:00
PHST- 2002/07/26 00:00 [received]
PHST- 2002/09/18 00:00 [accepted]
PHST- 2003/07/10 05:00 [pubmed]
PHST- 2003/11/07 05:00 [medline]
PHST- 2003/07/10 05:00 [entrez]
AID - 7800194 [pii]
AID - 10.1038/sj.mn.7800194 [doi]
PST - ppublish
SO  - Microcirculation. 2003 Jun;10(3-4):289-95. doi: 10.1038/sj.mn.7800194.