PMID- 12852493
OWN - NLM
STAT- MEDLINE
DCOM- 20031205
LR  - 20190922
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 49
IP  - 4
DP  - 2003 Apr
TI  - Pre-term birth and severe pre-eclampsia are not associated with altered 
      expression of HLA on human trophoblasts.
PG  - 193-201
AB  - PROBLEM: The unusual pattern of human leukocyte antigen (HLA) expression on human 
      trophoblasts could play an important role in successful pregnancy outcome. To 
      determine whether alterations in HLA expression are associated with pregnancy 
      abnormalities we have investigated expression of these antigens on chorionic and 
      extravillous cytotrophoblasts. METHODS: Frozen tissue sections of placenta and 
      fetal membranes were collected after pre-term spontaneous delivery, severe 
      pre-eclampsia pre-term Caesarean section, normal term delivery and term Caesarean 
      section. HLA expression was analyzed by immunohistochemistry. RESULTS: We did not 
      observe differences in the expression of HLA on chorionic and extravillous 
      cytotrophoblasts in pregnancy abnormalities. However, we noted higher expression 
      levels of HLA class Ia molecules in amnion epithelial cells in pre-term 
      deliveries. Furthermore, in severe pre-eclampsia the number of extravillous 
      cytotrophoblast islands were elevated when compared with pre-term deliveries. 
      CONCLUSIONS: No alterations in expression of HLA class Ia, HLA-G and HLA class II 
      on human trophoblasts in pregnancy abnormalities were seen.
FAU - Datema, Gert
AU  - Datema G
AD  - Department of Immunohematology and Blood Transfusion, Leiden University Medical 
      Center, Leiden, the Netherlands.
FAU - van Meir, Claudia A
AU  - van Meir CA
FAU - Kanhai, Humphrey H H
AU  - Kanhai HH
FAU - van den Elsen, Peter J
AU  - van den Elsen PJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Amnion/cytology/metabolism
MH  - Epithelial Cells/metabolism
MH  - Female
MH  - HLA Antigens/*biosynthesis
MH  - Humans
MH  - Immunohistochemistry
MH  - Obstetric Labor, Premature/*metabolism
MH  - Pre-Eclampsia/*metabolism
MH  - Pregnancy
MH  - Trophoblasts/*metabolism
EDAT- 2003/07/11 05:00
MHDA- 2003/12/06 05:00
CRDT- 2003/07/11 05:00
PHST- 2003/07/11 05:00 [pubmed]
PHST- 2003/12/06 05:00 [medline]
PHST- 2003/07/11 05:00 [entrez]
AID - 10.1034/j.1600-0897.2003.01182.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2003 Apr;49(4):193-201. doi: 
      10.1034/j.1600-0897.2003.01182.x.