PMID- 12852811
OWN - NLM
STAT- MEDLINE
DCOM- 20121211
LR  - 20030710
IS  - 1003-0603 (Print)
IS  - 1003-0603 (Linking)
VI  - 15
IP  - 1
DP  - 2003 Jan
TI  - [Effects of efferent vagus nerve excitation on inflammatory response in heart 
      tissue in rats with endotoxemia].
PG  - 26-8
AB  - OBJECTIVE: To study the effects of electrical stimulation of efferent vagus nerve 
      on the inflammatory response in heart tissue in rats with endotoxemia. METHODS: 
      Two hundred and ten Wistar rats were randomly divided into seven groups. Animals 
      were subjected to bilateral cervical vagotomy, or a comparable sham surgical 
      procedure in which the vagus nerves were isolated but not transected. The distal 
      end of a vagus nerve trunk was placed across bipolar electrodes connected to a 
      stimulation module and controlled by an acquisition system. Stimuli with constant 
      voltage (5 V, 2 ms, 1 Hz) were applied to the nerve for 20 minutes immediately 
      after administration of lipopolysaccharide (LPS, 10 mg/kg, E coli O111: B4, 
      Sigma), and then were repeated 2 times after each of 10 minutes interval. Blood 
      and tissue samples of these rats were collected at 1, 1.5 and 2 hours after LPS 
      administration in all groups. Tumor necrosis factor-alpha (TNF-alpha) and 
      myeloperoxidase (MPO) in heart tissue and serum MB isoenzyme of creatine 
      kinase(CK-MB) were determined. RESULTS: The electrical stimulation of the 
      efferent vagus nerve significantly decreased the contents of TNF-alpha and MPO in 
      heart tissue and CK-MB in serum, and alleviated myocardial inflammation in heart 
      tissue at all time points, especially at 1.5 hours after endotoxin challenge. 
      CONCLUSION: The results suggested that excitation of the efferent vagus nerve can 
      significantly alleviate the inflammatory response in the heart tissue, thus it 
      might produce a potential protective effect on the heart during endotoxemia in 
      rats.
FAU - Shi, De-guang
AU  - Shi DG
AD  - Burn Institute, 304th Hospital of People's Liberation Army, Beijing 100037, 
      China.
FAU - Hu, Sen
AU  - Hu S
FAU - Jiang, Xiao-guo
AU  - Jiang XG
FAU - Sun, Dan
AU  - Sun D
FAU - Jin, Hua
AU  - Jin H
FAU - Li, Jun-you
AU  - Li JY
FAU - Liu, Qi-lin
AU  - Liu QL
FAU - Sheng, Zhi-yong
AU  - Sheng ZY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
JT  - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo 
      weizhongbing jijiuyixue
JID - 9887521
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Electric Stimulation
MH  - Endotoxemia/*pathology
MH  - *Inflammation
MH  - Lipopolysaccharides
MH  - Male
MH  - Myocardium/*pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Vagus Nerve/*physiology
EDAT- 2003/07/11 05:00
MHDA- 2012/12/12 06:00
CRDT- 2003/07/11 05:00
PHST- 2003/07/11 05:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PHST- 2003/07/11 05:00 [entrez]
PST - ppublish
SO  - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Jan;15(1):26-8.