PMID- 12852989
OWN - NLM
STAT- MEDLINE
DCOM- 20031126
LR  - 20191107
IS  - 0369-8114 (Print)
IS  - 0369-8114 (Linking)
VI  - 51
IP  - 4
DP  - 2003 Jun
TI  - [Randomised study to evaluate the chronotolerance of a combination infusional 
      chemotherapy with 5-fluorouracil, folinic acid and carboplatin in non small cell 
      lung cancer (NSCLC) patients].
PG  - 204-5
AB  - An infusional ambulatory chronotherapy with 5-FU, folinic acid (FOL) and 
      carboplatin was administered to 45 advanced NSCLC patients. The patients were 
      randomised into 3 groups varying according to the time of administration peak of 
      drugs (reference hours: 4 a.m. for 5 FU (and FOL); 4 p.m. for carboplatin; +/-8 
      h). The reference schedule appeared best tolerated (regarding hematology and 
      mucositis). This study has prospectively validated the chronotolerance concepts 
      of this complex combination chemotherapy.
FAU - Focan, C
AU  - Focan C
AD  - Service d'oncologie medicale, clinique Saint-Joseph, rue de Hesbaye, 75, 4000, 
      Liege, Belgique. christian.focan@lescliniquesstjoseph.be
FAU - Kreutz, F
AU  - Kreutz F
FAU - Moeneclaye, N
AU  - Moeneclaye N
FAU - Focan-Henrard, D
AU  - Focan-Henrard D
LA  - fre
PT  - Clinical Trial
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Etude randomisee evaluant la chronotolerance d'une association de 
      5-fluorouracile, acide folinique et carboplatine chez des patients porteurs d'un 
      cancer pulmonaire non a petites cellules (CPNPC).
PL  - France
TA  - Pathol Biol (Paris)
JT  - Pathologie-biologie
JID - 0265365
RN  - BG3F62OND5 (Carboplatin)
RN  - Q573I9DVLP (Leucovorin)
RN  - U3P01618RT (Fluorouracil)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/adverse 
      effects/therapeutic use
MH  - Carboplatin/administration & dosage/adverse effects
MH  - Carcinoma, Non-Small-Cell Lung/*drug therapy
MH  - *Chronotherapy
MH  - Female
MH  - Fluorouracil/administration & dosage/adverse effects
MH  - Humans
MH  - Infusions, Intravenous
MH  - Leucovorin/administration & dosage/adverse effects
MH  - Lung Neoplasms/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Treatment Outcome
EDAT- 2003/07/11 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/07/11 05:00
PHST- 2003/07/11 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/07/11 05:00 [entrez]
AID - S0369811403000439 [pii]
AID - 10.1016/s0369-8114(03)00043-9 [doi]
PST - ppublish
SO  - Pathol Biol (Paris). 2003 Jun;51(4):204-5. doi: 10.1016/s0369-8114(03)00043-9.