PMID- 12853130
OWN - NLM
STAT- MEDLINE
DCOM- 20031118
LR  - 20190922
IS  - 0167-8760 (Print)
IS  - 0167-8760 (Linking)
VI  - 49
IP  - 1
DP  - 2003 Jul
TI  - A paradigm for measuring the olfactory event-related potential in the clinic.
PG  - 57-65
AB  - Recent research on the olfactory event-related potential (OERP) using 
      inter-stimulus intervals (ISIs) of 90 s and shorter has revealed a marked 
      decrease in component amplitude after the first trial, with a leveling off for 
      the remaining trials. Studies manipulating the ISI in olfactory and other 
      modalities demonstrate an association between higher amplitudes and longer ISIs, 
      suggesting that habituation occurs at short time intervals between each stimulus 
      presentation. The present study attempted to reduce the effects of habituation by 
      using a 10-min ISI and fewer trials. OERPs were recorded monopolarly at the Fz, 
      Cz and Pz electrode sites in ten subjects (five males, five females), for three 
      trials using a 10-min ISI. Results demonstrated no significant reduction in 
      component amplitudes across trials and no significant difference in latencies 
      over trials, indicating no habituation effect at this ISI. These results indicate 
      that with a 10-min ISI and three trial recordings, a complete reduction in 
      habituation can be achieved. These findings may prove to be clinically useful to 
      physicians who can implement this technique to assess olfactory functioning in 
      cognitively impaired individuals or to assess malingering.
FAU - Wetter, Spencer
AU  - Wetter S
AD  - SDSU/UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Ct. Suite 
      101, San Diego, CA, 92120-4913, USA.
FAU - Murphy, Claire
AU  - Murphy C
LA  - eng
GR  - R01 AG004085/AG/NIA NIH HHS/United States
GR  - AG04085/AG/NIA NIH HHS/United States
GR  - DC02064/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Int J Psychophysiol
JT  - International journal of psychophysiology : official journal of the International 
      Organization of Psychophysiology
JID - 8406214
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Clinical Trials as Topic/methods
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Habituation, Psychophysiologic/*physiology
MH  - Humans
MH  - Male
MH  - *Odorants
MH  - Sensory Thresholds/physiology
MH  - Smell/*physiology
EDAT- 2003/07/11 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/07/11 05:00
PHST- 2003/07/11 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/07/11 05:00 [entrez]
AID - S0167876003000795 [pii]
AID - 10.1016/s0167-8760(03)00079-5 [doi]
PST - ppublish
SO  - Int J Psychophysiol. 2003 Jul;49(1):57-65. doi: 10.1016/s0167-8760(03)00079-5.