PMID- 12853291 OWN - NLM STAT- MEDLINE DCOM- 20030825 LR - 20190616 IS - 0077-8923 (Print) IS - 0077-8923 (Linking) VI - 993 DP - 2003 May TI - Neuroprotection trek--the next generation: neuromodulation II. Applications--epilepsy, nerve regeneration, neurotrophins. PG - 14-24; discussion 48-53 AB - Three examples of neuroprotective applications of electrical stimulation-neuromodulation-are considered: (1) the diagnosis and treatment of epilepsy, (2) the augmentation of peripheral nerve regeneration after transection, and (3) the interaction between electrical stimulation and neurotrophins (notably brain derived neurotrophic factor [BDNF]) in various neuroprotective situations. The research cited demonstrates clear benefit from appropriate electrical stimulation in the treatment of (1) certain patients with medication-refractory epilepsy, and (2) the functional regeneration of peripheral nerves after transection and surgical repair. Furthermore, neuromodulation of peripheral nerve regeneration has been associated with an increase in the neurotrophin BDNF. The roles of BDNF and other neurotrophins in several disorders of the nervous system are discussed in the context of neuromodulation and its augmentation of neurotrophins. Neuromodulation-at least in part through its effect on BDNF and other neurotrophins-will likely play a major role in the treatment (and possibly prevention) of disorders of the nervous system for which neuroproteive pharmacologic agents have traditionally been sought. FAU - Andrews, Russell J AU - Andrews RJ AD - NASA Ames Research Center, Moffett Field, California, USA. rja@russelljandrews.org LA - eng PT - Journal Article PT - Review PL - United States TA - Ann N Y Acad Sci JT - Annals of the New York Academy of Sciences JID - 7506858 RN - 0 (Anticonvulsants) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (GDNF protein, human) RN - 0 (Glial Cell Line-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Neuroprotective Agents) SB - IM MH - Anticonvulsants/*therapeutic use MH - Brain-Derived Neurotrophic Factor/*therapeutic use MH - Depression/metabolism/therapy MH - *Electric Stimulation MH - *Electric Stimulation Therapy MH - Epilepsy/diagnosis/*therapy MH - Glial Cell Line-Derived Neurotrophic Factor MH - Humans MH - Magnetics/therapeutic use MH - Nerve Growth Factors/metabolism/therapeutic use MH - Nerve Regeneration/*physiology MH - Nervous System Diseases/therapy MH - Neuroprotective Agents/therapeutic use MH - Peripheral Nerves/physiology RF - 21 EDAT- 2003/07/11 05:00 MHDA- 2003/08/26 05:00 CRDT- 2003/07/11 05:00 PHST- 2003/07/11 05:00 [pubmed] PHST- 2003/08/26 05:00 [medline] PHST- 2003/07/11 05:00 [entrez] AID - 10.1111/j.1749-6632.2003.tb07507.x [doi] PST - ppublish SO - Ann N Y Acad Sci. 2003 May;993:14-24; discussion 48-53. doi: 10.1111/j.1749-6632.2003.tb07507.x.