PMID- 12854730
OWN - NLM
STAT- MEDLINE
DCOM- 20031210
LR  - 20190922
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 49
IP  - 5
DP  - 2003 May
TI  - Increased T-cell activation in decidua parietalis compared to decidua basalis in 
      uncomplicated human term pregnancy.
PG  - 261-8
AB  - PROBLEM: The aim of this study was to quantify and compare activated T cells in 
      term decidua basalis and parietalis using flow cytometry. METHOD OF STUDY: Term 
      decidua basalis and parietalis samples were obtained from 20 placentas collected 
      after elective caesarean section. Percentages of leukocyte subclasses within the 
      CD45+ cell fraction and activated T cells were determined by flow cytometry. 
      RESULTS: There was no significant difference in CD45+, CD14+, CD19+, and CD3+ 
      cell percentages. However, within the CD3+ population, there were significantly 
      more T-cell receptor-gamma(delta)+ (TCR-gamma(delta)-) and CD8+ cells in decidua 
      parietalis compared with decidua basalis. More importantly, percentages of T 
      cells expressing CD25, human leukocyte antigen (HLA)-DR, CD45RO, and CD69 markers 
      were significantly increased in decidua parietalis. CONCLUSION: These findings 
      suggest that there are more activated T cells in decidua parietalis than in 
      decidua basalis. Further investigation into differences between the two decidual 
      sites may expand our understanding of the immunology of the maternal-fetal 
      interface.
FAU - Sindram-Trujillo, A
AU  - Sindram-Trujillo A
AD  - Department of Immunohematology and Blood Transfusion, Leiden University Medical 
      Center, Leiden, The Netherlands.
FAU - Scherjon, S
AU  - Scherjon S
FAU - Kanhai, H
AU  - Kanhai H
FAU - Roelen, D
AU  - Roelen D
FAU - Claas, F
AU  - Claas F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (CD3 Complex)
SB  - IM
MH  - CD3 Complex/metabolism
MH  - Decidua/*immunology
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Pregnancy
MH  - T-Lymphocyte Subsets/immunology/metabolism
MH  - T-Lymphocytes/*immunology/metabolism
EDAT- 2003/07/12 05:00
MHDA- 2003/12/12 05:00
CRDT- 2003/07/12 05:00
PHST- 2003/07/12 05:00 [pubmed]
PHST- 2003/12/12 05:00 [medline]
PHST- 2003/07/12 05:00 [entrez]
AID - 10.1034/j.1600-0897.2003.00041.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2003 May;49(5):261-8. doi: 10.1034/j.1600-0897.2003.00041.x.