PMID- 12854889 OWN - NLM STAT- MEDLINE DCOM- 20031023 LR - 20190116 IS - 1042-8194 (Print) IS - 1026-8022 (Linking) VI - 44 IP - 6 DP - 2003 Jun TI - Cord blood dendritic cells: subsets, functional characteristics and in vitro generation. PG - 923-8 AB - Dendritic cells (DCs) form a heterogeneous population of cells capable of stimulating naive T cells and initiating primary immune responses. This well-known function of DCs has offered the possibility of developing clinical protocols for their use in immunotherapy to tumours. DCs may also play a critical role in the induction of peripheral immunological tolerance, which could have important implications in the treatment of autoimmunity or in the outcome of clinical transplantation. Recent reports have indicated that cord blood transplantation is associated with a reduced incidence of graft versus host disease. Thus studies on the identification and characterisation of DCs present in, or derived from cord blood will help to understand their role, not only in neonatal immunity, but also in the outcome of cord blood transplantation. FAU - Navarrete, Cristina V AU - Navarrete CV AD - Department of Histocompatibility and Immunogenetics, National Blood Service, Colindale Avenue, London NW9 5BG, UK. cristina.navarrete@nbs.nhs.uk FAU - Gomez, Jesus AU - Gomez J FAU - Borras, Francesc E AU - Borras FE LA - eng PT - Journal Article PT - Review PL - United States TA - Leuk Lymphoma JT - Leukemia & lymphoma JID - 9007422 RN - 0 (Antigens, CD) RN - 0 (Antigens, CD34) SB - IM MH - Animals MH - Antigens, CD/blood MH - Antigens, CD34/blood MH - Cell Differentiation MH - Dendritic Cells/*classification/*cytology MH - Fetal Blood/*cytology MH - Humans MH - Infant, Newborn RF - 41 EDAT- 2003/07/12 05:00 MHDA- 2003/10/24 05:00 CRDT- 2003/07/12 05:00 PHST- 2003/07/12 05:00 [pubmed] PHST- 2003/10/24 05:00 [medline] PHST- 2003/07/12 05:00 [entrez] AID - 10.1080/1042819031000068070 [doi] PST - ppublish SO - Leuk Lymphoma. 2003 Jun;44(6):923-8. doi: 10.1080/1042819031000068070.