PMID- 12855194
OWN - NLM
STAT- MEDLINE
DCOM- 20031008
LR  - 20190901
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 143
IP  - 2
DP  - 2003 Jul 12
TI  - Complexity in the modulation of neurotrophic factor mRNA expression by early 
      visual experience.
PG  - 225-32
AB  - The expression of mRNA for brain-derived neurotrophic factor (BDNF) is regulated 
      by early visual experience. In this study, we sought to determine whether other 
      neurotrophic factor mRNAs are similarly regulated. We reared pigmented rats from 
      birth to postnatal day 21 in a normal light cycle, constant light (LR) or 
      constant darkness (DR). In the retina, superior colliculus (SC), primary visual 
      cortex (V1), hippocampus (HIPP) and cerebellum (CBL), using a ribonuclease 
      protection assay (RPA), we examined expression of the mRNAs for nerve growth 
      factor (NGF), BDNF, NT3, NT4, ciliary neurotrophic factor (CNTF) and glial cell 
      line-derived neurotrophic factor (GDNF). LR or DR alter the expression of the 
      mRNAs for NGF, BDNF and NT3 and CNTF within the visual system. LR also 
      upregulated BDNF mRNA expression within the cerebellum. In all of the structures 
      examined, NT4 mRNA expression was unaltered by LR or DR and GDNF mRNA was 
      undetectable. Notably, the same rearing condition could induce changes of 
      opposite sign in the mRNA for a single factor in different structures or for 
      different factors in the same structure. Thus, during developmental stages when 
      sensory experience and neuroelectric activity are important in the shaping of 
      visual circuitry, vision regulates the expression of multiple neurotrophic factor 
      mRNAs and each mRNA has a unique profile with respect to the locus and sign of 
      activity-induced changes.
FAU - Pollock, Graeme S
AU  - Pollock GS
AD  - Department of Pharmacology and Experimental Therapeutics, University of Maryland 
      School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA.
FAU - Frost, Douglas O
AU  - Frost DO
LA  - eng
GR  - EY11434/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Nerve Growth Factors)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/*growth & development/metabolism
MH  - Darkness
MH  - *Gene Expression Regulation, Developmental
MH  - Light
MH  - Nerve Growth Factors/*biosynthesis/*genetics
MH  - Photic Stimulation
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Long-Evans
MH  - Retina/growth & development/metabolism
EDAT- 2003/07/12 05:00
MHDA- 2003/10/09 05:00
CRDT- 2003/07/12 05:00
PHST- 2003/07/12 05:00 [pubmed]
PHST- 2003/10/09 05:00 [medline]
PHST- 2003/07/12 05:00 [entrez]
AID - S0165380603001536 [pii]
AID - 10.1016/s0165-3806(03)00153-6 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2003 Jul 12;143(2):225-32. doi: 
      10.1016/s0165-3806(03)00153-6.