PMID- 12855243
OWN - NLM
STAT- MEDLINE
DCOM- 20031014
LR  - 20201208
IS  - 0195-6701 (Print)
IS  - 0195-6701 (Linking)
VI  - 54
IP  - 3
DP  - 2003 Jul
TI  - Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea.
PG  - 243-5
AB  - Clostridium difficile is the main infectious cause of colitis in hospital 
      inpatients. The incidence is increasing, and it is associated with significant 
      mortality, morbidity, and increased length of stay. The main risk factor is use 
      of broad-spectrum antibiotics, and antibiotic restriction is the most effective 
      control measure. We carried out a retrospective case-control study to investigate 
      whether use of proton pump inhibitors (PPI) was an additional risk factor. PPI 
      use within the preceding eight weeks was associated with an increased risk of C. 
      difficile diarrhoea (odds ratio 2.5, 95% CI 1.5-4.2). Reduction of unnecessary 
      PPI use may be an additional strategy to reduce the incidence of this infection.
FAU - Cunningham, R
AU  - Cunningham R
AD  - Plymouth Public Health Laboratory, Derriford Hospital, Plymouth, UK. 
      richard.cunningham@phnt.swest.nhs.uk
FAU - Dale, B
AU  - Dale B
FAU - Undy, B
AU  - Undy B
FAU - Gaunt, N
AU  - Gaunt N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Hosp Infect
JT  - The Journal of hospital infection
JID - 8007166
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Proton Pumps)
SB  - IM
MH  - Achlorhydria/etiology
MH  - *Clostridioides difficile
MH  - Clostridium Infections/*etiology
MH  - Diarrhea/*microbiology
MH  - Enzyme Inhibitors/*adverse effects
MH  - Hospitalization
MH  - Humans
MH  - Proton Pumps/*metabolism
MH  - Retrospective Studies
MH  - Risk Factors
EDAT- 2003/07/12 05:00
MHDA- 2003/10/15 05:00
CRDT- 2003/07/12 05:00
PHST- 2003/07/12 05:00 [pubmed]
PHST- 2003/10/15 05:00 [medline]
PHST- 2003/07/12 05:00 [entrez]
AID - S0195670103000884 [pii]
AID - 10.1016/s0195-6701(03)00088-4 [doi]
PST - ppublish
SO  - J Hosp Infect. 2003 Jul;54(3):243-5. doi: 10.1016/s0195-6701(03)00088-4.