PMID- 12855751
OWN - NLM
STAT- MEDLINE
DCOM- 20031027
LR  - 20081121
IS  - 1071-7323 (Print)
IS  - 1071-7323 (Linking)
VI  - 11
IP  - 7
DP  - 2003 Jul
TI  - Genetic contributions to body weight in mice: relationship of exploratory 
      behavior to weight.
PG  - 828-38
AB  - OBJECTIVE: The A/J and C57BL/6J mouse strains differ markedly in their 
      exploratory behavior and their weight gain on a high-fat diet. We examined the 
      genetic contributions of exploratory behavior to body weight and tested for 
      shared, pleiotropic loci influencing energy homeostasis. RESEARCH METHODS AND 
      PROCEDURES: Segregating (AxB6)F2 intercross (n = 514) and (B6AF1xA/J)N2 backcross 
      (N = 223) populations were studied, phenotyping for weight and exploratory 
      behaviors. Relationships among traits were analyzed by correlations. Weight 
      traits were dissected with a genome-wide scan. RESULTS: Modest correlations were 
      found between exploratory behaviors and weight, explaining 2% to 14% of the 
      variance. Quantitative trait loci (QTL) for body weight at 8 weeks (wgt8), 10 
      weeks (wgt10), and 2-week weight gain (difference between weeks 8 and 10) on a 6% 
      fat diet were mapped. Two QTL on chromosome 1 (peaks at 66 cM and 100 cM; Bw8q1) 
      affected wgt8 [likelihood of the odds ratio (Lod), 3.0 and 4.4] and wgt10 (Lod, 
      2.2 and 3.4), respectively. In the backcross, a significant QTL on chromosome 4 
      (peak at 66 cM; Bw8q2) affected wgt 8 (Lod, 3.3) and wgt10 (Lod, 3.1). For 2-week 
      weight gain, suggestive QTL were mapped on chromosomes 4 and 6. The chromosome 6 
      QTL region overlaps a human 7q locus for obesity. A search for between-strain 
      sequence polymorphisms in the leptin and NPY genes was unrevealing. DISCUSSION: 
      In mice, loci influencing exploratory activity play a modest role in body-weight 
      regulation. Some forms of obesity may emerge from loci regulating normal body 
      weight.
FAU - Zhang, Shumin
AU  - Zhang S
AD  - Department of Psychiatry, University of Texas Southwestern Medical Center, 
      Dallas, TX 75235-8898, USA.
FAU - Gershenfeld, Howard K
AU  - Gershenfeld HK
LA  - eng
GR  - R01-MH58882/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Obes Res
JT  - Obesity research
JID - 9305691
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Body Weight/*genetics
MH  - Chromosome Mapping
MH  - Dietary Fats/administration & dosage
MH  - Energy Metabolism
MH  - *Exploratory Behavior
MH  - Female
MH  - Genetic Variation
MH  - Genotype
MH  - Male
MH  - Mice
MH  - Mice, Inbred A
MH  - Mice, Inbred C57BL
MH  - Phenotype
MH  - Quantitative Trait Loci
MH  - Weight Gain
EDAT- 2003/07/12 05:00
MHDA- 2003/10/28 05:00
CRDT- 2003/07/12 05:00
PHST- 2003/07/12 05:00 [pubmed]
PHST- 2003/10/28 05:00 [medline]
PHST- 2003/07/12 05:00 [entrez]
AID - 10.1038/oby.2003.114 [doi]
PST - ppublish
SO  - Obes Res. 2003 Jul;11(7):828-38. doi: 10.1038/oby.2003.114.