PMID- 1285652
OWN - NLM
STAT- MEDLINE
DCOM- 19930311
LR  - 20190902
IS  - 0340-3696 (Print)
IS  - 0340-3696 (Linking)
VI  - 284 Suppl 1
DP  - 1992
TI  - Peptides and cytokines.
PG  - S22-6
AB  - In the last decade a number of proteinaceous inflammatory mediators have been 
      structurally characterized. Two of these mediators, tumor necrosis factor alpha 
      (TNF alpha) and Interleukin 1 alpha and beta (IL-1), have pleiotropic properties. 
      Both cytokines are now known to be potent inducers of a number of cell-selective 
      chemotactic cytokines, which belong to a novel superfamily of structurally 
      related low-molecular-weight proteins. One of the most prominent members is 
      termed "IL-8" and represents a neutrophil-selective attractant, whereas another 
      one called "monocyte chemotactic protein 1 (MCP-1)" is a monocyte-selective 
      chemotaxin. Other members seem to be selective chemotaxins for other leukocyte 
      types and subsets. These chemotactic cytokines are produced by a variety of 
      different cells under appropriate stimulation conditions. Large amounts of IL-8 
      have been detected in scales of psoriatic lesions and may be of importance in 
      explaining predominant neutrophil infiltration in psoriatic lesions. Regulation 
      of gene expression and/or release of these chemotactic cytokines may occur by 
      IL-1 receptor antagonists or soluble TNF-alpha-receptors. So far, natural 
      antagonists to these chemotactic cytokines have not been described; however, 
      pharmacological inhibition of its gene expression and/or release is possible.
FAU - Schroder, J M
AU  - Schroder JM
AD  - Department of Dermatology, University of Kiel, Federal Republic of Germany.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chemokine CCL2
MH  - Chemotactic Factors/analysis/*physiology
MH  - Cytokines/analysis/genetics/*physiology
MH  - Dermatitis/*etiology
MH  - Gene Expression
MH  - Humans
MH  - Interleukin-8/analysis/*physiology
MH  - Molecular Sequence Data
MH  - Tumor Necrosis Factor-alpha/physiology
RF  - 35
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1007/BF00638236 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 1992;284 Suppl 1:S22-6. doi: 10.1007/BF00638236.