PMID- 12857597
OWN - NLM
STAT- MEDLINE
DCOM- 20040227
LR  - 20181113
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 12
IP  - 3
DP  - 2003 Jun
TI  - Slight respiratory irritation but not inflammation in mice exposed to 
      (1-->3)-beta-D-glucan aerosols.
PG  - 139-46
AB  - Airway irritation effects after single and repeated inhalation exposures to 
      aerosols of beta-glucan (grifolan) were investigated in mice. In addition, the 
      effects on serum total immunoglobulin E (IgE) production and histopathological 
      inflammation in the respiratory tract were studied. The beta-glucan aerosols 
      provoked slight sensory irritation in the airways, but the response was not 
      concentration dependent at the levels studied. Slight pulmonary irritation was 
      observed after repeated exposures. No effect was found on the serum total IgE 
      levels, and no signs of inflammation were seen in the airways 6 h after the final 
      exposure. The results suggest that, irrespective of previous fungal sensitization 
      of the animals, inhaled beta-glucan may cause symptoms of respiratory tract 
      irritation but without apparent inflammation. Respiratory tract irritation 
      reported after inhalation of fungi may not be entirely attributed to beta-glucan.
FAU - Korpi, A
AU  - Korpi A
AD  - Department of Environmental Sciences University of Kuopio Neulaniementie 2 70211 
      P.O. Box 1627 Kuopio. anne.korpi@uku.fi
FAU - Kasanen, J-P
AU  - Kasanen JP
FAU - Kosma, V-M
AU  - Kosma VM
FAU - Rylander, R
AU  - Rylander R
FAU - Pasanen, A-L
AU  - Pasanen AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Aerosols)
RN  - 0 (Glucans)
RN  - 0 (beta-Glucans)
RN  - 104074-36-4 (grifolan)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Aerosols
MH  - Animals
MH  - Female
MH  - Glucans/*administration & dosage
MH  - Immunization
MH  - Immunoglobulin E/metabolism
MH  - Lung/drug effects/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Respiratory Mechanics/drug effects
MH  - Respiratory System/*drug effects/pathology
MH  - Stachybotrys/immunology
MH  - Time Factors
MH  - *beta-Glucans
PMC - PMC1781604
EDAT- 2003/07/15 05:00
MHDA- 2004/02/28 05:00
PMCR- 2003/06/01
CRDT- 2003/07/15 05:00
PHST- 2003/07/15 05:00 [pubmed]
PHST- 2004/02/28 05:00 [medline]
PHST- 2003/07/15 05:00 [entrez]
PHST- 2003/06/01 00:00 [pmc-release]
AID - 6264J011HUC9YF2P [pii]
AID - 10.1080/0962935031000134851 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2003 Jun;12(3):139-46. doi: 10.1080/0962935031000134851.