PMID- 12858410
OWN - NLM
STAT- MEDLINE
DCOM- 20031007
LR  - 20061115
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 71
IP  - 1
DP  - 2003 Sep
TI  - Human herpesvirus 6 infection of human epidermal cell line: pathogenesis of skin 
      manifestations.
PG  - 62-8
AB  - In order to elucidate the pathogenesis of variant B human herpesvirus 6 (HHV-6) 
      infection in skin tissues, an A431 cell line was inoculated with variant B HHV-6. 
      HHV-6 causes abortive infection in the A431 cells, because neither late antigen 
      (OHV-3 antigen) nor progeny virus is produced. Maximum levels of HHV-6 antigen 
      (IEA/ex3 antigen)-positive cells (36.4%) were observed 48 hr after viral 
      infection. Cocultivation of HHV-6-infected cord blood mononuclear cells with A431 
      cells was necessary for the establishment of a sufficient level of viral 
      infection. Cell-to-cell contact between the infected cord blood mononuclear cells 
      and A431 cells was crucial for increasing infection efficiency. To determine the 
      biological effect of HHV-6 infection, flow cytometric analysis was carried out in 
      HHV-6- and mock-infected A431 cells. Although no alteration was observed in 
      VCAM-1 and ELAM-1 expression, that of HLA-ABC, HLA-DR, and ICAM-1 was upregulated 
      after infection with HHV-6.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Yoshikawa, Tetsushi
AU  - Yoshikawa T
AD  - Laboratory of Virology, Research Institute for Disease Mechanism and Control, 
      Nagoya University School of Medicine, Nagoya, Aichi, Japan. 
      tetsushi@fujita-hu.ac.jp
FAU - Goshima, Fumi
AU  - Goshima F
FAU - Akimoto, Shiho
AU  - Akimoto S
FAU - Ozaki, Takao
AU  - Ozaki T
FAU - Iwasaki, Takuya
AU  - Iwasaki T
FAU - Kurata, Takeshi
AU  - Kurata T
FAU - Asano, Yoshizo
AU  - Asano Y
FAU - Nishiyama, Yukihiro
AU  - Nishiyama Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (HLA Antigens)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Cell Line
MH  - Epidermis/metabolism/*pathology/*virology
MH  - Flow Cytometry
MH  - Gene Expression Regulation
MH  - HLA Antigens/metabolism
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - Intercellular Adhesion Molecule-1/metabolism
EDAT- 2003/07/15 05:00
MHDA- 2003/10/08 05:00
CRDT- 2003/07/15 05:00
PHST- 2003/07/15 05:00 [pubmed]
PHST- 2003/10/08 05:00 [medline]
PHST- 2003/07/15 05:00 [entrez]
AID - 10.1002/jmv.10461 [doi]
PST - ppublish
SO  - J Med Virol. 2003 Sep;71(1):62-8. doi: 10.1002/jmv.10461.