PMID- 12859287
OWN - NLM
STAT- MEDLINE
DCOM- 20031003
LR  - 20190814
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 108
IP  - 2
DP  - 2003 Aug
TI  - Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction.
PG  - 109-13
AB  - OBJECTIVES: To test the hypothesis whether risk genotypes of the prothrombotic 
      gene polymorphisms (I/D 4G5G PAI-1, G1691A factor V point mutation, factor VII 
      Arg/Gln353) are risk factors for ACI in the Slovene population. The study sought 
      an association between the insertion/deletion 4G/5G-plasminogen activator 
      inhibitor 1 (PAI-1) gene polymorphism, the 1691G-A factor V point mutation or the 
      arg353-to-gln factor VII gene polymorphism and atherothrombotic cerebral 
      infarction (ACI). MATERIAL AND METHODS: Ninety-six Slovene patients who suffered 
      ACI were compared with 115 control subjects clinically free of cerebrovascular 
      disease. Insertion/deletion 4G/5G PAI-1 gene polymorphism, 1691G-A factor V point 
      mutation and arg353-to-gln polymorphism in the factor VII were determined using 
      polymerase chain reaction. RESULTS: The 4G4G genotype of 4G5G PAI-1 gene 
      polymorphism was less frequent in cases (21.9%) than in controls (35.6%; OR = 
      0.5, 95% CI = 0.3-1; P = 0.033). No association was found either between the 
      factor V point mutation (1691G-A) or the RR genotype of the factor VII Arg/Gln353 
      gene polymorphism and the risk of ACI using univariate analysis. CONCLUSION: The 
      4G/4G-PAI-1 genotype might be a protective factor against ACI, whereas the factor 
      V point mutation (1691G-A) and the factor VII Arg/Gln353 gene polymorphism have 
      not proved to be risk factors for ACI.
FAU - Petrovic, D
AU  - Petrovic D
AD  - Institute of Histology and Embryology, Medical Faculty Ljubljana, Ljubljana, 
      Slovenia. daniel.petrovic@mf.uni-lj.si
FAU - Milanez, T
AU  - Milanez T
FAU - Kobal, J
AU  - Kobal J
FAU - Bregar, D
AU  - Bregar D
FAU - Potisk, K P
AU  - Potisk KP
FAU - Peterlin, B
AU  - Peterlin B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 9001-24-5 (Factor V)
RN  - 9001-25-6 (Factor VII)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Cerebral Infarction/*genetics
MH  - Factor V/*genetics
MH  - Factor VII/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Plasminogen Activator Inhibitor 1/*genetics
MH  - *Point Mutation
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Slovenia
EDAT- 2003/07/16 05:00
MHDA- 2003/10/04 05:00
CRDT- 2003/07/16 05:00
PHST- 2003/07/16 05:00 [pubmed]
PHST- 2003/10/04 05:00 [medline]
PHST- 2003/07/16 05:00 [entrez]
AID - 126 [pii]
AID - 10.1034/j.1600-0404.2003.00126.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2003 Aug;108(2):109-13. doi: 10.1034/j.1600-0404.2003.00126.x.