PMID- 12859337
OWN - NLM
STAT- MEDLINE
DCOM- 20030929
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 18
IP  - 1
DP  - 2003 Jul
TI  - Firing regulation in dopaminergic cells: effect of the partial degeneration of 
      nigrostriatal system in surviving neurons.
PG  - 53-60
AB  - Two mechanisms for firing rate regulation were identified in dopaminergic 
      nigrostriatal cells (DA cells), one of a renewal nature which prevents short and 
      long interspike intervals (ISIs) and the other of a no-renewal nature which 
      compensates long ISIs with short ISIs and vice versa. Renewal regulation was 
      found in 96% of DA cells and less frequently in nigrocollicular (63%), 
      nigrothalamic (61%) and nigropeduncular (50%) nigral GABA cells. No-renewal 
      regulation was found in 77% of DA cells, and was only observed in 8% of GABA 
      cells. Thus, most DA cells showed both regulatory mechanisms, which justifies the 
      low variability in their firing rate and the low oscillation of extracellular 
      striatal dopamine previously reported. DA cells surviving a partial degeneration 
      of the nigrostriatal system did not show alterations in their firing rate and 
      burst firing but presented a marked disturbance for no-renewal regulation. Under 
      these conditions, small fluctuations in firing rate are not compensated for in 
      time, which could be one of the factors responsible for the motor fluctuations 
      often observed in advanced Parkinson's disease.
FAU - Rodriguez, Manuel
AU  - Rodriguez M
AD  - Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, 
      Canary Islands, Spain. mrdiaz@ull.es
FAU - Gonzalez, Julian
AU  - Gonzalez J
FAU - Sabate, Magdalena
AU  - Sabate M
FAU - Obeso, Jose
AU  - Obeso J
FAU - Pereda, Ernesto
AU  - Pereda E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Sympatholytics)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Cell Survival/physiology
MH  - Dopamine/*physiology
MH  - Electrophysiology
MH  - Male
MH  - Markov Chains
MH  - Motor Neurons/physiology
MH  - Neurons/*physiology
MH  - Oxidopamine
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Striatonigral Degeneration/*physiopathology
MH  - Sympathectomy, Chemical
MH  - Sympatholytics
MH  - gamma-Aminobutyric Acid/physiology
EDAT- 2003/07/16 05:00
MHDA- 2003/09/30 05:00
CRDT- 2003/07/16 05:00
PHST- 2003/07/16 05:00 [pubmed]
PHST- 2003/09/30 05:00 [medline]
PHST- 2003/07/16 05:00 [entrez]
AID - 2723 [pii]
AID - 10.1046/j.1460-9568.2003.02723.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2003 Jul;18(1):53-60. doi: 10.1046/j.1460-9568.2003.02723.x.