PMID- 12859556
OWN - NLM
STAT- MEDLINE
DCOM- 20031125
LR  - 20190823
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 58
IP  - 8
DP  - 2003 Aug
TI  - Subjects with allergic rhinitis show signs of more severely impaired paranasal 
      sinus functioning during viral colds than nonallergic subjects.
PG  - 767-71
AB  - BACKGROUND: Viral cold is thought to be the major contributing factor in the 
      pathogenesis of sinusitis, as it causes ostiomeatal obstruction. The aim was to 
      evaluate whether paranasal sinus functioning during viral colds is similar in 
      subjects with and without allergic rhinitis. METHODS: Forty-eight volunteers were 
      examined during an early (2-4 days) natural cold and again 3 weeks later. The 
      examinations included computed tomography (CT) scans, nasal mucosal biopsies, and 
      viral and bacterial specimens. Subjects with positive skin prick tests and 
      persistent or intermittent rhinitis were considered to have allergic 
      immunoglobulin E (IgE)-mediated rhinitis. In addition, specific IgE antibodies to 
      staphylococcal enterotoxin B (SEB) were measured. RESULTS: Nine subjects (19%) 
      had allergic rhinitis. The allergic subjects were significantly more often IgE 
      sensitized to SEB than the nonallergic subjects (33%vs 3%, P = 0.02). Viral 
      etiology of the cold was identified in 32 (67%) subjects. The subjects with 
      allergic rhinitis had significantly higher CT scores compared with nonallergic 
      subjects during the colds (median (range) scores 16 (6-22) vs 6 (0-17), P = 
      0.004). In both groups, the median scores declined markedly during convalescence, 
      but the difference remained significant (P = 0.009). Among the allergic subjects, 
      those who were IgE sensitized to SEB tended to have the highest CT scores [median 
      (range) 16 (16-22)]. Total serum IgE and the nasal subepithelial eosinophil 
      counts correlated with the CT scores during the cold (rs = 0.38, P = 0.008 and rs 
      = 0.46, P = 0.001, respectively). CONCLUSIONS: Subjects with allergic 
      IgE-mediated rhinitis had more severe paranasal sinus changes in CT scans than 
      nonallergic subjects during viral colds. These changes indicate impaired sinus 
      functioning and may increase the risk of bacterial sinusitis.
FAU - Alho, O-P
AU  - Alho OP
AD  - Department of Otorhinolaryngology, University of Oulu, Finland.
FAU - Karttunen, T J
AU  - Karttunen TJ
FAU - Karttunen, R
AU  - Karttunen R
FAU - Tuokko, H
AU  - Tuokko H
FAU - Koskela, M
AU  - Koskela M
FAU - Suramo, I
AU  - Suramo I
FAU - Uhari, M
AU  - Uhari M
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Common Cold/*complications/virology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Nasal Mucosa/*pathology
MH  - Paranasal Sinuses/*diagnostic imaging
MH  - Rhinitis, Allergic, Perennial/*complications/*diagnostic 
      imaging/immunology/pathology
MH  - Rhinitis, Allergic, Seasonal/*complications/*diagnostic 
      imaging/immunology/pathology
MH  - Sinusitis/etiology
MH  - Tomography, X-Ray Computed
EDAT- 2003/07/16 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/07/16 05:00
PHST- 2003/07/16 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/07/16 05:00 [entrez]
AID - 252 [pii]
AID - 10.1034/j.1398-9995.2003.00252.x [doi]
PST - ppublish
SO  - Allergy. 2003 Aug;58(8):767-71. doi: 10.1034/j.1398-9995.2003.00252.x.