PMID- 12859728
OWN - NLM
STAT- MEDLINE
DCOM- 20070403
LR  - 20190901
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 18
IP  - 8
DP  - 2003 Aug
TI  - Expression of adhesion molecules in the rectum-associated lymph nodules of pre- 
      and postnatal specific pathogen-free rats.
PG  - 970-9
AB  - BACKGROUND AND AIM: The developmental process of lymphoid tissues in the 
      gastrointestinal tract is still unclear. The aim of the present study was to 
      explore the expression of adhesion molecule in rectum-associated lymph nodules 
      (RALN) of specific pathogen-free (SPF) rats at fetal and early postnatal periods 
      of development. METHODS: Immunohistochemical analysis was carried out of select 
      adhesion molecules and lymphocyte subsets in lymph nodules of the rat rectal 
      region. RESULTS: Mucosal addressin cell adhesion molecule (MAdCAM)-1 expression 
      was detected in the colonic mucosa on day 16 of gestation. Expression was strong 
      in endothelial cells of all blood vessels in the entire colonic mucosa until day 
      7 after birth. On day 10 after birth, MAdCAM-1 was strongly expressed and 
      confined to the high endothelial venule (HEV) in the submucosa of RALN, and was 
      rarely detected in the blood vessels other than the HEV. In contrast, 
      intercellular adhesion molecule (ICAM)-1 expression was absent in fetal colonic 
      mucosa but appeared just after birth. Only a very small number of 
      lymphocyte-function associated antigen (LFA)-1-positive cells appeared in the 
      mucosa on day 16 of gestation but by day 19 of gestation a large number of these 
      cells had rapidly aggregated in the mucosa of the ante-mesenteric side of the 
      developing colon. These cells also expressed interleukin-7 receptor (IL-7R), and 
      some were positive for CD4 and Mar-1 markers. CONCLUSION: The region of RALN 
      undergoes rapid and dynamic changes in adhesion molecule expression during 
      gestation, which may regulate interactions with intestine-associated immune cells 
      shortly after birth.
FAU - Ichikawa, Sanae
AU  - Ichikawa S
AD  - Department of Anatomy, Tokyo Medical University, Tokyo, Japan. 
      marve@tokyo-med.ac.jp
FAU - Yamashita, Akira
AU  - Yamashita A
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Fetus
MH  - Immunoenzyme Techniques
MH  - Intercellular Adhesion Molecule-1/*metabolism
MH  - Lymph Nodes/embryology/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Rectum/embryology/*metabolism
MH  - Specific Pathogen-Free Organisms
EDAT- 2003/07/16 05:00
MHDA- 2007/04/04 09:00
CRDT- 2003/07/16 05:00
PHST- 2003/07/16 05:00 [pubmed]
PHST- 2007/04/04 09:00 [medline]
PHST- 2003/07/16 05:00 [entrez]
AID - 3096 [pii]
AID - 10.1046/j.1440-1746.2003.03096.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2003 Aug;18(8):970-9. doi: 
      10.1046/j.1440-1746.2003.03096.x.