PMID- 12859859
OWN - NLM
STAT- MEDLINE
DCOM- 20040217
LR  - 20131121
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 23
IP  - 6
DP  - 2003 Jun
TI  - Elevated plasma amylase levels in advanced chronic heart failure secondary to 
      ischemic or idiopathic dilated cardiomyopathy: correlation with circulating 
      interleukin-6 activity.
PG  - 329-33
AB  - It has been reported that proinflammatory cytokine activation is associated with 
      both mesenteric venous congestion and peripheral tissue underperfusion in 
      advanced chronic heart failure. The aim of our study was to investigate if plasma 
      amylase (as an easily approached marker of a low-grade peripheral organ injury 
      caused by elevated systemic venous pressure and reduced cardiac output) is 
      elevated in severe heart failure and if this elevation is correlated with 
      cytokine and neurohormonal activation in the plasma of heart failure patients. 
      Plasma levels of amylase, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 
      (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), 
      norepinephrine, and renin activity were measured in 43 severe heart failure 
      patients (ischemic, 28; dilated, 15; left ventricular ejection fraction [LVEF] 27 
      +/- 3%; New York Heart Association [NYHA] classes III-IV), in 37 mild heart 
      failure patients (ischemic, 26; dilated, 11; LVEF, 33 +/- 5%; NYHA classes I-II), 
      and in 20 age-matched and gender-matched healthy controls. NYHA III-IV heart 
      failure patients exhibited significantly higher plasma levels of amylase (342 +/- 
      19 vs. 174 +/- 13 U/L, p < 0.01), TNF-alpha (6.2 +/- 0.5 vs. 4.2 +/- 0.3 pg/ml, p 
      < 0.01), IL-6 (5.9 +/- 0.3 vs. 4.4 +/- 0.3 pg/ml, p < 0.05), GM-CSF (21.2 +/- 2.7 
      vs. 4.1 +/- 0.9 pg/ml, p < 0.001), and neurohormones (both p < 0.001) compared 
      with NYHA I-II heart failure patients and healthy controls (amylase, 165 +/- 11 
      U/L, p < 0.01; TNF-alpha, 2.7 +/- 0.3 pg/ml, p < 0.001; IL-6, 3.2 +/- 0.2 pg/ml, 
      p < 0.01; GM-CSF, 3.1 +/- 0.7 pg/ml, p < 0.001). Only in NYHA III-IV heart 
      failure patients, plasma amylase levels were significantly correlated with plasma 
      IL-6 activity (r = 0.86, p < 0.001), plasma norepinephrine levels (r = 0.82, p < 
      0.001) and right atrial pressure (r = 0.52, p < 0.05). Additionally, circulating 
      IL-6 was also significantly correlated with plasma norepinephrine (r = 0.86, p < 
      0.001) and right atrial pressure (r = 0.57, p < 0.01). In conclusion, plasma 
      amylase levels were elevated in severe heart failure patients and correlated well 
      with circulating IL-6 activation, possibly as a result of both mesenteric venous 
      congestion and impaired peripheral tissue perfusion observed in advanced chronic 
      heart failure. However, the lack of association between plasma IL-6 and amylase 
      levels in mild heart failure patients indicates an independent correlation of 
      each variable with the functional status of the disease.
FAU - Parissis, John T
AU  - Parissis JT
AD  - First Department of Cardiology, Amalia Fleming Hospital, Athens, Greece. 
      jparissis@yahoo.com
FAU - Adamopoulos, Stamatis N
AU  - Adamopoulos SN
FAU - Venetsanou, Koula F
AU  - Venetsanou KF
FAU - Karas, Spilios M
AU  - Karas SM
FAU - Kremastinos, Dimitrios T
AU  - Kremastinos DT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Interleukin-6)
RN  - EC 3.2.1.- (Amylases)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Amylases/*blood
MH  - Cardiac Output, Low/*blood/etiology/*immunology
MH  - Cardiomyopathy, Dilated/*complications
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*complications
MH  - Norepinephrine/analysis
MH  - Prospective Studies
EDAT- 2003/07/16 05:00
MHDA- 2004/02/18 05:00
CRDT- 2003/07/16 05:00
PHST- 2003/07/16 05:00 [pubmed]
PHST- 2004/02/18 05:00 [medline]
PHST- 2003/07/16 05:00 [entrez]
AID - 10.1089/107999003766628179 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2003 Jun;23(6):329-33. doi: 
      10.1089/107999003766628179.