PMID- 12860057
OWN - NLM
STAT- MEDLINE
DCOM- 20040326
LR  - 20191210
IS  - 1532-0456 (Print)
IS  - 1532-0456 (Linking)
VI  - 135
IP  - 2
DP  - 2003 Jun
TI  - Copper homeostasis and toxicity in the elasmobranch Raja erinacea and the teleost 
      Myoxocephalus octodecemspinosus during exposure to elevated water-borne copper.
PG  - 179-90
AB  - Clear nosed skate, Raja erinacea were exposed to 0.10 (control), 0.52 or 1.73 
      microM copper and sculpin, Myoxocephalus octodecemspinosus were exposed to 0.10 
      or 1.73 microM copper (as CuSO4) in Salisbury Cove seawater for up to seven days. 
      Skate gill copper concentrations increased 40-50 fold over background in response 
      to copper exposure at both concentrations. In comparison, sculpin gill levels 
      only increased 3-fold. While there was no evidence for internalized copper in the 
      skate arising from the water-borne exposure, sculpin kidneys, but not livers, 
      exhibited elevated copper concentrations after the seven days of exposure. The 
      marked difference in branchial copper accumulation between the skate and the 
      sculpin likely explains why elasmobranchs appear to be more sensitive to metal 
      exposure than most marine teleost fish. Brain tissue from both species and the 
      skate rectal gland contained relatively high background copper concentrations. 
      Copper exposure caused an initial transient reduction in skate plasma total 
      ammonia (Tamm), but eventually led to elevated plasma Tamm. Despite the marked 
      branchial copper accumulation in the skate, there was no reduction in gill 
      Na/K-ATPase activity. Similarly, Na/K-ATPase activity in skate rectal gland and 
      intestine, as well as in sculpin gill and intestine were not affected by copper 
      exposure. Plasma sodium, magnesium and chloride were not affected by copper 
      exposure in either the skate or the sculpin.
FAU - Grosell, Martin
AU  - Grosell M
AD  - Mount Desert Island Biological Laboratories, Salisbury Cove, Maine 04672, USA. 
      mgrosell@rsmas.miami.edu
FAU - Wood, Chris M
AU  - Wood CM
FAU - Walsh, Patrick J
AU  - Walsh PJ
LA  - eng
GR  - ES05705/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Comp Biochem Physiol C Toxicol Pharmacol
JT  - Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
JID - 100959500
RN  - 0 (Electrolytes)
RN  - 0 (Water Pollutants, Chemical)
RN  - 789U1901C5 (Copper)
RN  - EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
SB  - IM
MH  - Animals
MH  - Copper/*pharmacokinetics/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Elasmobranchii/*metabolism
MH  - Electrolytes/blood
MH  - Fishes/*metabolism
MH  - Hematocrit
MH  - *Homeostasis
MH  - Sodium-Potassium-Exchanging ATPase/metabolism
MH  - Time Factors
MH  - Tissue Distribution
MH  - Water Pollutants, Chemical/*pharmacokinetics/*toxicity
EDAT- 2003/07/16 05:00
MHDA- 2004/03/27 05:00
CRDT- 2003/07/16 05:00
PHST- 2003/07/16 05:00 [pubmed]
PHST- 2004/03/27 05:00 [medline]
PHST- 2003/07/16 05:00 [entrez]
AID - S1532045603000899 [pii]
AID - 10.1016/s1532-0456(03)00089-9 [doi]
PST - ppublish
SO  - Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jun;135(2):179-90. doi: 
      10.1016/s1532-0456(03)00089-9.