PMID- 12860078
OWN - NLM
STAT- MEDLINE
DCOM- 20031118
LR  - 20220316
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 95
IP  - 1-2
DP  - 2003 Aug 29
TI  - Interleukin 6, serum amyloid A and haptoglobin as markers of treatment efficacy 
      in pigs experimentally infected with Actinobacillus pleuropneumoniae.
PG  - 75-89
AB  - The possibility to use acute phase proteins to monitor the elimination of a 
      bacterial infection in pigs would facilitate an objective assessment of treatment 
      with various antimicrobial substances. To examine this possibility, the acute 
      phase response (IL-6, serum amyloid A (SAA), and haptoglobin) elicited by 
      Actinobacillus pleuropneumoniae and its reduction on treatment with various 
      antibiotics was studied in serum from specific pathogen free (SPF) pigs. Pigs 
      were infected intranasally with A. pleuropneumoniae serotype 2, and either left 
      as non-treated control pigs or treated with different antibiotics intramuscularly 
      at onset of respiratory disease (20h post-infection). Pigs responded to the 
      infection with prominent increases in activity and concentrations of IL-6, SAA, 
      and haptoglobin. These responses were to a certain extent overlapping and covered 
      the time span from a few hours after infection until development of detectable 
      levels of specific antibodies (7-10 days post-infection in untreated pigs). The 
      haptoglobin response lasted until the end of the study on day 17 and thereby 
      partly coincided with the antibody response. Treatment with antimicrobials that 
      effectively reduced establishment of the infection with A. pleuropneumoniae also 
      reduced the duration of all three acute phase responses, and reduced the 
      concentration of serum haptoglobin. In contrast, less efficacious treatments did 
      not reduce these acute phase responses. Thus, acute phase reactants can be 
      applied to monitor therapeutic effects of antimicrobial drugs in the pig and 
      measurements of IL-6, SAA and haptoglobin could add valuable information about 
      the stage of infection during a disease outbreak.
FAU - Hulten, C
AU  - Hulten C
AD  - Department of Clinical Chemistry, P.O. Box 7038, Uppsala, Sweden.
FAU - Johansson, E
AU  - Johansson E
FAU - Fossum, C
AU  - Fossum C
FAU - Wallgren, P
AU  - Wallgren P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Apolipoproteins)
RN  - 0 (Haptoglobins)
RN  - 0 (Interleukin-6)
RN  - 0 (Serum Amyloid A Protein)
SB  - IM
MH  - Actinobacillus Infections/blood/drug therapy/microbiology/*veterinary
MH  - Actinobacillus pleuropneumoniae/*growth & development
MH  - Acute-Phase Reaction/blood/drug therapy/microbiology/veterinary
MH  - Animals
MH  - Anti-Bacterial Agents/*pharmacology/therapeutic use
MH  - Antibodies, Bacterial/blood
MH  - Apolipoproteins/*blood
MH  - Female
MH  - Haptoglobins/*metabolism
MH  - Interleukin-6/*blood
MH  - Lung/microbiology/pathology
MH  - Male
MH  - Pleuropneumonia/blood/drug therapy/microbiology/*veterinary
MH  - Serum Amyloid A Protein
MH  - Specific Pathogen-Free Organisms
MH  - Swine
MH  - Swine Diseases/*blood/drug therapy/microbiology
EDAT- 2003/07/16 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/07/16 05:00
PHST- 2003/07/16 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/07/16 05:00 [entrez]
AID - S0378113503001366 [pii]
AID - 10.1016/s0378-1135(03)00136-6 [doi]
PST - ppublish
SO  - Vet Microbiol. 2003 Aug 29;95(1-2):75-89. doi: 10.1016/s0378-1135(03)00136-6.