PMID- 12860285
OWN - NLM
STAT- MEDLINE
DCOM- 20030925
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 196
IP  - 1
DP  - 2003 Jun 30
TI  - Bi-allelic inactivation of the MEN1 tumor suppressor gene in human grade II 
      astrocytoma.
PG  - 23-7
AB  - In humans and gene-targeted mice, loss of multiple endocrine neoplasia type 1 
      (MEN1) tumor suppressor gene function causes neuroendocrine tumors, frequently of 
      the parathyroid and pituitary glands and the pancreas. The MEN1 gene product 
      interacts with glial fibrillary acidic protein (GFAP) in the brain. We here 
      demonstrate bi-allelic MEN1 inactivation in a grade II astrocytoma in an 
      individual carrying a heterozygous MEN1 germ line deletion mutation (788del6). 
      This tumor represents a novel, non-endocrine MEN1-phenotype, compatible with a 
      role of MEN1-GFAP in glial oncogenesis. Clinically, a genetic predisposition to 
      variant neoplasias should be considered in the management of MEN1 patients.
FAU - Karges, Wolfram
AU  - Karges W
AD  - Division of Endocrinology, Department of Internal Medicine 1, University of Ulm, 
      Robert Koch Strasse 8, 89081 Ulm, Germany. wolfram.karges@medizin.uni-ulm.de
FAU - Karges, Beate
AU  - Karges B
FAU - Ludwig, Leopold
AU  - Ludwig L
FAU - Heidemann, Peter H
AU  - Heidemann PH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Astrocytoma/*genetics
MH  - Base Sequence
MH  - Brain Neoplasms/*genetics
MH  - Child
MH  - *Genes, Tumor Suppressor
MH  - Germ-Line Mutation
MH  - Humans
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/complications
MH  - Neoplasm Proteins/*genetics
MH  - *Proto-Oncogene Proteins
EDAT- 2003/07/16 05:00
MHDA- 2003/09/26 05:00
CRDT- 2003/07/16 05:00
PHST- 2003/07/16 05:00 [pubmed]
PHST- 2003/09/26 05:00 [medline]
PHST- 2003/07/16 05:00 [entrez]
AID - S0304383503001800 [pii]
AID - 10.1016/s0304-3835(03)00180-0 [doi]
PST - ppublish
SO  - Cancer Lett. 2003 Jun 30;196(1):23-7. doi: 10.1016/s0304-3835(03)00180-0.