PMID- 12864989
OWN - NLM
STAT- MEDLINE
DCOM- 20031023
LR  - 20190827
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 140
IP  - 1-2
DP  - 2003 Jul
TI  - High innate production of interleukin-10 and tumor necrosis factor-alpha 
      contributes to susceptibility for non-paraneoplastic Lambert-Eaton myasthenic 
      syndrome.
PG  - 194-7
AB  - Non-paraneoplastic Lambert-Eaton myasthenic syndrome (LEMS) is an 
      antibody-mediated autoimmune disorder, in which genetically determined 
      interleukin-10 (Il-10) and tumor necrosis factor-alpha (TNF-alpha) could play a 
      role in the susceptibility for the disease. Therefore, we analyzed the production 
      of Il-10 and TNF-alpha after whole-blood stimulation in first-degree family 
      members of patients with LEMS without malignancy, as a measure of innate 
      production in the patients. Thirty-six first-degree family members of 10 patients 
      and 80 healthy controls were studied. Both Il-10 (p=0.037) and TNF-alpha 
      (p=0.0016) production were increased in the family members, but had no relation 
      with the severity of LEMS or HLA-B8DR3 carriership. Our findings suggest that 
      high innate production of Il-10 and TNF-alpha is a susceptibility factor for 
      non-paraneoplastic LEMS.
FAU - Wirtz, Paul W
AU  - Wirtz PW
AD  - Department of Neurology, Leiden University Medical Center, P.O. Box 9600, 2300 
      RC, Leiden, The Netherlands. pwwirtz@lumc.nl
FAU - Huizinga, Tom W J
AU  - Huizinga TW
FAU - Stoeken, Dirk-Jan
AU  - Stoeken DJ
FAU - Wintzen, Axel R
AU  - Wintzen AR
FAU - Verschuuren, Jan J
AU  - Verschuuren JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - Disease Susceptibility/immunology
MH  - Female
MH  - Humans
MH  - Immunity, Innate/genetics
MH  - Interleukin-10/*biosynthesis
MH  - Lambert-Eaton Myasthenic Syndrome/genetics/*immunology
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
MH  - Up-Regulation/genetics/*immunology
EDAT- 2003/07/17 05:00
MHDA- 2003/10/24 05:00
CRDT- 2003/07/17 05:00
PHST- 2003/07/17 05:00 [pubmed]
PHST- 2003/10/24 05:00 [medline]
PHST- 2003/07/17 05:00 [entrez]
AID - S0165572803002054 [pii]
AID - 10.1016/s0165-5728(03)00205-4 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2003 Jul;140(1-2):194-7. doi: 10.1016/s0165-5728(03)00205-4.