PMID- 12865128
OWN - NLM
STAT- MEDLINE
DCOM- 20030821
LR  - 20220410
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 347
IP  - 1
DP  - 2003 Aug 14
TI  - Acupuncture suppresses ischemia-induced increase in c-Fos expression and 
      apoptosis in the hippocampal CA1 region in gerbils.
PG  - 5-8
AB  - Acupuncture has been used for the enhancement of functional recovery from various 
      disorders including stroke. In the present study, the effects of acupuncture on 
      the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils 
      following transient global ischemia were investigated via immunohistochemistry 
      for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP 
      nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities 
      were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural 
      treatment suppressed the ischemia-induced increment in the number of Fos-, 
      TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was 
      observed at the Zusanli acupoint. These results suggest that acupunctural 
      treatment alleviates ischemia-induced apoptosis and may aid in the recovery 
      following ischemic cerebral injury.
FAU - Jang, Mi-Hyeon
AU  - Jang MH
AD  - Department of Physiology, College of Medicine, Kyung Hee University, # 1 
      Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
FAU - Shin, Min-Chul
AU  - Shin MC
FAU - Lee, Taeck-Hyun
AU  - Lee TH
FAU - Lim, Baek-Vin
AU  - Lim BV
FAU - Shin, Mal-Soon
AU  - Shin MS
FAU - Min, Byung-Il
AU  - Min BI
FAU - Kim, Hong
AU  - Kim H
FAU - Cho, Sonhae
AU  - Cho S
FAU - Kim, Ee-Hwa
AU  - Kim EH
FAU - Kim, Chang-Ju
AU  - Kim CJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - *Acupuncture Therapy
MH  - Animals
MH  - *Apoptosis
MH  - Brain Ischemia/*metabolism/pathology
MH  - Caspase 3
MH  - Caspases/metabolism
MH  - Gerbillinae
MH  - Hippocampus/*metabolism/pathology
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Proto-Oncogene Proteins c-fos/*metabolism
EDAT- 2003/07/17 05:00
MHDA- 2003/08/22 05:00
CRDT- 2003/07/17 05:00
PHST- 2003/07/17 05:00 [pubmed]
PHST- 2003/08/22 05:00 [medline]
PHST- 2003/07/17 05:00 [entrez]
AID - S0304394003005123 [pii]
AID - 10.1016/s0304-3940(03)00512-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 2003 Aug 14;347(1):5-8. doi: 10.1016/s0304-3940(03)00512-3.