PMID- 1286883
OWN - NLM
STAT- MEDLINE
DCOM- 19930315
LR  - 20191028
IS  - 0171-2985 (Print)
IS  - 0171-2985 (Linking)
VI  - 186
IP  - 5
DP  - 1992 Nov
TI  - Functional analyses of lpr gene in MRL/Mp-lpr/lpr mice. Role of lymph node 
      stromal cells in lpr-lymphadenopathy.
PG  - 449-65
AB  - To clarify the mechanism by which the lpr gene causes lymphadenopathy, we 
      established an experimental system to induce lymph node (LN) swelling in 
      unaffected mice. In MRL-(+)/+ mice that had been 5 Gy-irradiated and grafted with 
      bone marrow cells (BMCs) plus LN from MRL-lpr/lpr mice, a remarkable enlargement 
      of the LN grafts was seen. The enlarged grafts lacked normal LN structure and 
      were indistinguishable from LNs of MRL-lpr/lpr mice. The induction of LN swelling 
      by this method was achieved not only in [MRL-lpr/lpr-->MRL-(+)/+] but also in 
      [MRL-lpr/lpr-->BALB/c], [MRL-lpr/lpr-->C3H], [B6-lpr/lpr-->B10.Thy1.1], and 
      [B6-lpr/lpr-->BALB/c] combinations. Furthermore, the lpr/lpr LN grafts developed 
      lymph node swelling even without the transplantation of BMCs. Most cells in the 
      grafted LNs disappeared within a few days, and large clear fibroblast-like cells 
      then became dominant for 1 to 4 weeks. Thereafter, lymphoid cells increased and 
      had filled the graft by the 8th week. The LN grafts obtained from MRL-lpr/lpr 
      (but not MRL-(+)/+) mice showed the ability to transfer LN node swelling into the 
      secondary MRL-(+)/+ hosts two weeks after the primary transplantation. These 
      results strongly suggest that the fibroblast-like LN stromal cells play a crucial 
      role in lpr-associated lymphadenopathy.
FAU - Ohnishi-Inoue, Y
AU  - Ohnishi-Inoue Y
AD  - First Department of Pathology, Kansai Medical University, Osaka, Japan.
FAU - Yasumizu, R
AU  - Yasumizu R
FAU - Sugiura, K
AU  - Sugiura K
FAU - Nagata, N
AU  - Nagata N
FAU - Fan, H
AU  - Fan H
FAU - Oyaizu, N
AU  - Oyaizu N
FAU - Inaba, M
AU  - Inaba M
FAU - Toki, J
AU  - Toki J
FAU - Ikehara, S
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
SB  - IM
GS  - lpr
MH  - Animals
MH  - Autoimmune Diseases/*genetics/immunology
MH  - Bone Marrow Transplantation/immunology
MH  - Fibroblasts/pathology
MH  - *Genes
MH  - Genotype
MH  - Hypertrophy
MH  - Immunotherapy, Adoptive
MH  - Lymph Nodes/immunology/*pathology/transplantation
MH  - Lymphatic Diseases/*etiology/immunology/pathology
MH  - Lymphoproliferative Disorders/*genetics/immunology
MH  - Mice
MH  - Mice, Inbred BALB C/genetics/immunology
MH  - Mice, Inbred Strains/*genetics/immunology
MH  - Mice, Mutant Strains/*genetics/immunology
MH  - Phenotype
MH  - Radiation Chimera
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - S0171-2985(11)80397-9 [pii]
AID - 10.1016/s0171-2985(11)80397-9 [doi]
PST - ppublish
SO  - Immunobiology. 1992 Nov;186(5):449-65. doi: 10.1016/s0171-2985(11)80397-9.