PMID- 12869799 OWN - NLM STAT- MEDLINE DCOM- 20030826 LR - 20171101 IS - 0028-3835 (Print) IS - 0028-3835 (Linking) VI - 78 IP - 1 DP - 2003 Jul TI - Steroid receptor coactivator-1 is not required for androgen-mediated sexual differentiation of spinal motoneurons. PG - 45-51 AB - Steroid receptor coactivator-1 (SRC-1) amplifies genomic steroid hormone signal transduction and has been implicated in steroid-mediated sexual differentiation of the mammalian nervous system. We investigated the possible effect of an SRC-1 null mutation on 2 morphological endpoints of androgenic signaling: the number and size of motoneurons within the spinal nucleus of the bulbocavernosus (SNB). In wild-type C57/BL6 mice, SRC-1 immunoreactive nuclei were observed within the SNB and one of its target muscles, the levator ani. However, SRC-1 null mice were indistinguishable from sex-matched wild-type littermates in both SNB number and cross-sectional area of SNB motoneurons. Similarly, we found no difference between SRC-1 null and wildtype littermates in the number or size of motoneurons in the retrodorsolateral nucleus, a motor pool that is not typically sexually differentiated in either number or size. These results demonstrate that SRC-1 is not essential for the development and maintenance of a sexually dimorphic neuromuscular system. CI - Copyright 2003 S. Karger AG, Basel FAU - Monks, Douglas A AU - Monks DA AD - Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA. FAU - Xu, Jianming AU - Xu J FAU - O'Malley, Bert W AU - O'Malley BW FAU - Jordan, Cynthia L AU - Jordan CL LA - eng GR - R01 U54 DK58242/DK/NIDDK NIH HHS/United States GR - R01 U54 NS045795/NS/NINDS NIH HHS/United States GR - R01 U54 NS28421/NS/NINDS NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S. PL - Switzerland TA - Neuroendocrinology JT - Neuroendocrinology JID - 0035665 RN - 0 (Androgens) RN - 0 (Receptors, Steroid) RN - 0 (Transcription Factors) RN - EC 2.3.1.48 (Histone Acetyltransferases) RN - EC 2.3.1.48 (Ncoa1 protein, mouse) RN - EC 2.3.1.48 (Nuclear Receptor Coactivator 1) SB - IM MH - Androgens/*physiology MH - Animals MH - Histone Acetyltransferases MH - Mice MH - Mice, Inbred C57BL MH - Mice, Knockout MH - Motor Neurons/*metabolism MH - Muscle, Skeletal/innervation MH - Nuclear Receptor Coactivator 1 MH - Receptors, Steroid/*metabolism MH - *Sex Differentiation MH - Spinal Cord/cytology/*metabolism MH - Transcription Factors/genetics/*metabolism EDAT- 2003/07/19 05:00 MHDA- 2003/08/27 05:00 CRDT- 2003/07/19 05:00 PHST- 2003/03/10 00:00 [received] PHST- 2003/05/05 00:00 [accepted] PHST- 2003/07/19 05:00 [pubmed] PHST- 2003/08/27 05:00 [medline] PHST- 2003/07/19 05:00 [entrez] AID - 71705 [pii] AID - 10.1159/000071705 [doi] PST - ppublish SO - Neuroendocrinology. 2003 Jul;78(1):45-51. doi: 10.1159/000071705.