PMID- 12869844
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20220408
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 33
IP  - 4
DP  - 2003 Aug 1
TI  - Globin haplotypes of human T-cell lymphotropic virus type I-infected individuals 
      in Salvador, Bahia, Brazil, suggest a post-Columbian African origin of this 
      virus.
PG  - 536-42
AB  - The city of Salvador, Bahia, Brazil, has sociodemographic characteristics similar 
      to some African cities. Up to now, it has had the highest prevalence of human 
      T-cell lymphotropic virus type I (HTLV-I) infection (1.74%) in the country. To 
      investigate which strains of HTLV-I are circulating in Salvador, we studied 
      isolates from 82 patients infected with HTLV-I: 19 from the general population, 
      21 from pregnant women, 16 from intravenous drug users, and 26 from patients and 
      their family attending a neurologic clinic. Phylogenetic analysis from part of 
      the LTR fragments showed that most of these isolates belonged to the 
      Transcontinental subgroup of the Cosmopolitan subtype (HTLV-Ia). Only one sample 
      from a pregnant woman was closely related to the Japanese subgroup, suggesting 
      recent introduction of a Japanese HTLV-I lineage into Salvador. betaA-Globin 
      haplotypes were examined in 34 infected individuals and found to be atypical, 
      confirming the racial heterogeneity of this population. A total of 20 chromosomes 
      were characterized as Central African Republic (CAR) haplotype (29.4%), 31 
      (45.6%) were characterized as Benin (BEN) haplotype, and 17 (25%) were 
      characterized as Senegal (SEN) haplotype. Five patients' genotypes (14.7%) were 
      CAR/CAR; 10 (29,4%), BEN/BEN; 9 (26.5%), CAR/BEN; 2 (5.9%), BEN/SEN; and 7 
      (20.6%), SEN/SEN. One patient's genotype (2.9%) was CAR/SEN. The betaA-globin 
      haplotype distribution in Salvador is unusual compared with other Brazilian 
      states. Our data support the hypothesis of multiple post-Columbian introductions 
      of African HTLV-Ia strains in Salvador, Bahia, Brazil.
FAU - Alcantara, Luiz Carlos Jr
AU  - Alcantara LC Jr
AD  - Goncalo Moniz Research Center, Oswaldo Cruz Foundation, Bahia, Brazil.
FAU - Van Dooren, Sonia
AU  - Van Dooren S
FAU - Goncalves, Marilda Souza
AU  - Goncalves MS
FAU - Kashima, Simone
AU  - Kashima S
FAU - Costa, Maria Cristina Ramos
AU  - Costa MC
FAU - Santos, Fred Luciano Neves
AU  - Santos FL
FAU - Bittencourt, Achilea Lisboa
AU  - Bittencourt AL
FAU - Dourado, Ines
AU  - Dourado I
FAU - Filho, Antonio Andrade
AU  - Filho AA
FAU - Covas, Dimas Tadeu
AU  - Covas DT
FAU - Vandamme, Anne-Mieke
AU  - Vandamme AM
FAU - Galvao-Castro, Bernardo
AU  - Galvao-Castro B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 9004-22-2 (Globins)
SB  - IM
MH  - Brazil
MH  - Globins/*genetics
MH  - HTLV-I Infections/*virology
MH  - *Haplotypes
MH  - Human T-lymphotropic virus 1/*classification
MH  - Humans
MH  - Phylogeny
MH  - Terminal Repeat Sequences
EDAT- 2003/07/19 05:00
MHDA- 2004/08/25 05:00
CRDT- 2003/07/19 05:00
PHST- 2003/07/19 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2003/07/19 05:00 [entrez]
AID - 10.1097/00126334-200308010-00016 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2003 Aug 1;33(4):536-42. doi: 
      10.1097/00126334-200308010-00016.