PMID- 12871757
OWN - NLM
STAT- MEDLINE
DCOM- 20040322
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 472
IP  - 3
DP  - 2003 Jul 11
TI  - Systemic anaphylaxis is prevented in alloxan-diabetic rats by a mechanism 
      dependent on glucocorticoids.
PG  - 221-7
AB  - This study was undertaken to examine whether glucocorticoids could be implicated 
      in the hyporesponsiveness of diabetic rats to systemic anaphylaxis. Rats were 
      actively sensitized with a mixture of Al(OH)(3) plus ovalbumin and challenged 
      i.v. with ovalbumin 14 days later. Diabetes was induced by alloxan-injected i.v. 
      either before or after sensitization. Elevation of total and specific serum 
      immunoglobulin E (IgE) was abolished in rats turned diabetic and then sensitised, 
      but not in those first sensitised and then turned diabetic. In both conditions, 
      increased serum corticosterone levels occurred in parallel with protection of 
      diabetic animals against fatal shock, intestinal haemorrhage and elevation in 
      plasma histamine levels evoked by antigen challenge. The resistance of diabetic 
      rats to fatal shock was no longer significantly different from that of 
      non-diabetic rats following treatment with the glucocorticoid receptor antagonist 
      RU 486 (mifepristone). These findings indicate that endogenous glucocorticoid 
      plays a pivotal role in the phenomenon of hyporeactivity to systemic anaphylaxis 
      in alloxan-diabetic rats.
FAU - Carvalho, Vinicius F
AU  - Carvalho VF
AD  - Laboratorio de Inflamacao, Departamento de Fisiologia e Farmacodinamica, 
      Instituto Oswaldo Cruz, FIOCRUZ, Av. Brasil, no. 4365, Manguinhos, CEP 21045-900, 
      Rio de Janeiro, Brazil.
FAU - Barreto, Emiliano O
AU  - Barreto EO
FAU - Diaz, Bruno L
AU  - Diaz BL
FAU - Serra, Magda F
AU  - Serra MF
FAU - Azevedo, Viviane
AU  - Azevedo V
FAU - Cordeiro, Renato S B
AU  - Cordeiro RS
FAU - Martins, Marco A
AU  - Martins MA
FAU - e Silva, Patricia M R
AU  - e Silva PM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Glucocorticoids)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 320T6RNW1F (Mifepristone)
SB  - IM
MH  - Anaphylaxis/*blood/*prevention & control
MH  - Animals
MH  - Diabetes Mellitus, Experimental/*blood
MH  - Glucocorticoids/*blood
MH  - Male
MH  - Mifepristone/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Glucocorticoid/*antagonists & inhibitors/metabolism
EDAT- 2003/07/23 05:00
MHDA- 2004/03/23 05:00
CRDT- 2003/07/23 05:00
PHST- 2003/07/23 05:00 [pubmed]
PHST- 2004/03/23 05:00 [medline]
PHST- 2003/07/23 05:00 [entrez]
AID - S0014299903019344 [pii]
AID - 10.1016/s0014-2999(03)01934-4 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2003 Jul 11;472(3):221-7. doi: 10.1016/s0014-2999(03)01934-4.