PMID- 12872193
OWN - NLM
STAT- MEDLINE
DCOM- 20030904
LR  - 20101118
IS  - 0946-7211 (Print)
IS  - 0946-7211 (Linking)
VI  - 46
IP  - 3
DP  - 2003 Jun
TI  - Brain biopsy prior to treatment of Alzheimer's disease.
PG  - 161-4
AB  - A cortical biopsy was analyzed using immunohistochemical methodology in a total 
      of 213 patients with suspected normal pressure hydrocephalus (NPH). Normal 
      intracranial pressure (ICP) was registered in 121 (43 %) of patients with 
      suspected NPH. The incidence of Alzheimer's disease (AD) related lesions was 
      quite high, since 38 % of all subjects displayed beta-amyloid (betaA4) aggregates 
      and in 8 % of subjects paired helical filament-tau (PHF-tau) pathology was noted. 
      The AD associated pathologies were more common in subjects with normal than 
      elevated ICP. Of the 121 subjects with NPH, 16 (13 %) had subclinical, 
      histopathologically verified AD and a further 40 subjects (33 %) could be 
      considered to be at high risk to develop AD. Pharmacological treatment trials of 
      AD should be carried out on subjects with evident brain pathology (betaA4 
      aggregates or PHF-tau pathology) especially during the early stage of the 
      disease, i.e., the subclinical stage. For this purpose a simple cortical biopsy 
      with a low risk of complication would represent a diagnostic "method" of choice.
FAU - Holm, A
AU  - Holm A
AD  - Department of Neuroscience and Neurology, Kuopio University, Kuopio, Finland.
FAU - Savolainen, S
AU  - Savolainen S
FAU - Alafuzoff, I
AU  - Alafuzoff I
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Minim Invasive Neurosurg
JT  - Minimally invasive neurosurgery : MIN
JID - 9440973
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*pathology/therapy
MH  - Amyloid beta-Peptides/*analysis
MH  - Biopsy
MH  - Cerebral Cortex/*physiology
MH  - Female
MH  - Humans
MH  - Hydrocephalus, Normal Pressure/*pathology
MH  - Immunohistochemistry
MH  - Male
MH  - Predictive Value of Tests
MH  - Risk Factors
EDAT- 2003/07/23 05:00
MHDA- 2003/09/05 05:00
CRDT- 2003/07/23 05:00
PHST- 2003/07/23 05:00 [pubmed]
PHST- 2003/09/05 05:00 [medline]
PHST- 2003/07/23 05:00 [entrez]
AID - 10.1055/s-2003-40733 [doi]
PST - ppublish
SO  - Minim Invasive Neurosurg. 2003 Jun;46(3):161-4. doi: 10.1055/s-2003-40733.