PMID- 12875480
OWN - NLM
STAT- MEDLINE
DCOM- 20040304
LR  - 20220311
IS  - 0803-7051 (Print)
IS  - 0803-7051 (Linking)
VI  - 12
IP  - 3
DP  - 2003
TI  - Anatomical basis for the fastigial pressor response.
PG  - 175-80
AB  - Electrical stimulation of rostromedial portion of cerebellar fastigial nucleus 
      elicits integrated cardiovascular effects, which are neurally and humorally 
      mediated. In this study, we sought to demonstrate the anatomical substrates of 
      the fastigial pressor response (FPR) in the rat. The response was 
      electrophysiologically localized in anesthetized, paralyzed-ventilated rats. 
      Anterograde transport techniques were used to study the efferent projections of 
      the fastigial pressor area; the distribution of efferent projection cells were 
      then mapped by injecting retrograde tracers into anterogradely labeled sites. 
      Electrolytic lesions were then placed bilaterally in selected brainstem areas in 
      the attempt to block the pressor response. Sites of cerebellar stimulation and of 
      brainstem lesions were subsequently histologically identified. The following 
      lesions abolished the FPR: in nine animals lesions involved portions of the 
      nucleus gigantocellularis dorsalis (NGCd), paramedian reticular formation (PMN) 
      and the nucleus tractus solitarii (NTS) (in two animals fairly selectively the 
      caudal NTS); in two other animals lesions destroyed the rostral ventrolateral 
      medulla (C1 area) and in one animal the area encompassing the dorsal convexity of 
      the superior cerebellar peduncle bordering the locus coeruleus-lateral 
      parabrachial complex; partially effective were unilateral lesions of NGCd and NTS 
      (three), bilateral lesions confined to NGCd and PMN (two), to vestibular complex 
      and uncinate fasciculus (UF) (three), to UF and locus coeruleus (three) and to 
      nucleus reticularis ventralis (two). Ineffective lesions involved A1 area, the 
      nucleus gigantocellularis ventralis (NGCv), the spinal trigeminal nucleus and 
      nucleus reticularis parvocellularis, the A5 area of the ventrolateral pons, the 
      central gray and lateral mesencephalic tegmentum. It seems therefore that the 
      pressor response elicited by stimulation of the cerebellar fastigial nucleus 
      utilizes central specific pathways, as lesions involving other brainstem regions 
      also known to participate in cardiovascular control do not affect the response. 
      Furthermore, the FPR persisted after midbrain decerebration, thus demonstrating 
      that it is organized beneath the midbrain.
FAU - Giuditta, Marianna
AU  - Giuditta M
AD  - Centro di Fisiologia Clinica e Ipertensione, Universita e Ospedale Maggiore di 
      Milano, Italy. giuditta_emme@libero.it
FAU - Ruggiero, David A
AU  - Ruggiero DA
FAU - Del Bo, Alberto
AU  - Del Bo A
LA  - eng
PT  - Journal Article
PL  - England
TA  - Blood Press
JT  - Blood pressure
JID - 9301454
SB  - IM
MH  - Animals
MH  - Blood Pressure/*physiology
MH  - Brain Stem/injuries
MH  - Cardiovascular Physiological Phenomena
MH  - Cerebellar Nuclei/*anatomy & histology/*physiology
MH  - Electric Stimulation
MH  - Rats
EDAT- 2003/07/24 05:00
MHDA- 2004/03/05 05:00
CRDT- 2003/07/24 05:00
PHST- 2003/07/24 05:00 [pubmed]
PHST- 2004/03/05 05:00 [medline]
PHST- 2003/07/24 05:00 [entrez]
AID - 10.1080/08037050310010912 [doi]
PST - ppublish
SO  - Blood Press. 2003;12(3):175-80. doi: 10.1080/08037050310010912.