PMID- 12876204
OWN - NLM
STAT- MEDLINE
DCOM- 20031224
LR  - 20240414
IS  - 1525-1578 (Print)
IS  - 1525-1578 (Linking)
VI  - 5
IP  - 3
DP  - 2003 Aug
TI  - Molecular genetics of pediatric soft tissue tumors: clinical application.
PG  - 143-54
AB  - The application of molecular genetics to pediatric soft tissue tumors has grown 
      tremendously over the last decade. It has resulted in the identification of novel 
      genes that have provided us with an increased understanding of oncogenesis. 
      Furthermore, these findings have identified diagnostic and potentially prognostic 
      factors for patient management. Molecular diagnostic techniques, such as reverse 
      transcription PCR (RT-PCR) and fluorescence in situ hybridization (FISH), have 
      become important tools for evaluating pediatric soft tissue tumors. By detecting 
      characteristic fusion genes, these techniques have greatly increased the 
      diagnostic accuracy of histopathological classification. One of the exciting 
      promises of the development of these molecular techniques is their ability to 
      detect micrometastasis and minimal residual disease. Monitoring of minimal 
      residual disease in pediatric soft tissue tumors by quantitative RT-PCR may 
      provide important prognostic information. Furthermore, the potential development 
      of targeted therapy based on the understanding of the molecular pathology of a 
      specific soft tissue tumor may complement existing treatments and improve disease 
      outcome.
FAU - Chang, Chung-Che
AU  - Chang CC
AD  - Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA. 
      jeffchang@pol.net
FAU - Shidham, Vinod B
AU  - Shidham VB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Mol Diagn
JT  - The Journal of molecular diagnostics : JMD
JID - 100893612
SB  - IM
MH  - Child
MH  - Chromosome Aberrations
MH  - Humans
MH  - Neoplasm, Residual
MH  - Prognosis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Soft Tissue Neoplasms/classification/diagnosis/*genetics/pathology
PMC - PMC1907327
EDAT- 2003/07/24 05:00
MHDA- 2003/12/25 05:00
PMCR- 2004/08/01
CRDT- 2003/07/24 05:00
PHST- 2003/07/24 05:00 [pubmed]
PHST- 2003/12/25 05:00 [medline]
PHST- 2003/07/24 05:00 [entrez]
PHST- 2004/08/01 00:00 [pmc-release]
AID - S1525-1578(10)60466-7 [pii]
AID - 0131 [pii]
AID - 10.1016/S1525-1578(10)60466-7 [doi]
PST - ppublish
SO  - J Mol Diagn. 2003 Aug;5(3):143-54. doi: 10.1016/S1525-1578(10)60466-7.