PMID- 12878355
OWN - NLM
STAT- MEDLINE
DCOM- 20040312
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 8
DP  - 2003 Aug
TI  - Pemphigus vulgaris in Jewish patients is associated with HLA-A region genes: 
      mapping by microsatellite markers.
PG  - 771-9
AB  - Pemphigus vulgaris (PV) is the most severe autoimmune blistering disorder of the 
      skin that is mediated by circulating autoantibodies against desmoglein 3 (Dsg3). 
      It has been reported that in Jews the associated haplotype in PV is human 
      leukocyte antigen (HLA) B38, DRB1*0402, DQB1*0302. Significant associations with 
      HLA were observed also in non-Jews. Dsg3-specific T-cell responses were detected 
      in PV patients but also in healthy individuals who were either carriers of the 
      PV-associated DRB1*0402 allele or alleles that share similar or identical peptide 
      binding motifs to DRB1*0402. This suggests that genes other than the classical 
      major histocompatibility complex (MHC) genes are associated with the development 
      of the autoimmune response. We used 16 microsatellite probes that span the entire 
      MHC region to screen DNA samples from 38 PV patients and 76 healthy controls. 
      Results demonstrated that some markers were associated with class II region 
      including a TAP associated marker. However, four probes, D6S265, C_527, D6S510, 
      and MOGC, which are all mapped to the region of HLA-A, were highly associated 
      with PV. These results suggest that a gene, or genes in the class I region are 
      important in the initiation of the autoimmune cascade. Activation/suppression of 
      these genes might act as the trigger mechanism that starts the autoimmune 
      destructive process.
FAU - Slomov, Elena
AU  - Slomov E
AD  - Tissue Typing Laboratory, Sheba Medical Center, Ramat Gan, Israel.
FAU - Loewenthal, Ron
AU  - Loewenthal R
FAU - Goldberg, Ilan
AU  - Goldberg I
FAU - Korostishevsky, Michael
AU  - Korostishevsky M
FAU - Brenner, Sara
AU  - Brenner S
FAU - Gazit, Ephraim
AU  - Gazit E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (HLA-A Antigens)
RN  - 0 (TAP1 protein, human)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP-Binding Cassette Transporters/genetics
MH  - *Chromosome Mapping
MH  - Gene Frequency
MH  - *Genes, MHC Class I
MH  - Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-A Antigens/*genetics/immunology
MH  - Humans
MH  - Israel
MH  - Jews/*genetics
MH  - *Microsatellite Repeats
MH  - Pemphigus/ethnology/*genetics/immunology
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic
EDAT- 2003/07/25 05:00
MHDA- 2004/03/16 05:00
CRDT- 2003/07/25 05:00
PHST- 2003/07/25 05:00 [pubmed]
PHST- 2004/03/16 05:00 [medline]
PHST- 2003/07/25 05:00 [entrez]
AID - S0198885903000922 [pii]
AID - 10.1016/s0198-8859(03)00092-2 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Aug;64(8):771-9. doi: 10.1016/s0198-8859(03)00092-2.