PMID- 12878360
OWN - NLM
STAT- MEDLINE
DCOM- 20040312
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 8
DP  - 2003 Aug
TI  - HLA class II genotypic frequencies in atopic asthma: association of 
      DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma.
PG  - 811-5
AB  - Different human leukocyte antigen (HLA) class II alleles have been associated 
      with the development of atopic asthma. To determine whether HLA class II alleles 
      are associated with atopic asthma in a population from southeast Spain (Murcia 
      region), 213 atopic asthmatic patients and 150 controls were selected for HLA 
      typing. Significant association of the DRB1*01 and DQB1*0501 alleles was found in 
      Artemisia vulgaris allergic patients (p(c) = 0.00052 and p(c) = 0.00023, 
      respectively). No significant correlation was found in other atopic patients 
      allergic to pollens (Phleum pratense, Olea europaea, and Salsola kali), house 
      dust mites (Dermatophagoides pteronyssinus, D. farinae), molds (Alternaria 
      alternata, Cladosporium herbarum), or animal danders (dog, cat). The results 
      reveal that the DRB1*01-DQB1*0501 genotype is strongly associated with a positive 
      response to Artemisia vulgaris in the population studied.
FAU - Torio, Alberto
AU  - Torio A
AD  - Immunology Service, University Hospital "Virgen de la Arrixaca", Murcia, Spain. 
      altorio@um.es
FAU - Sanchez-Guerrero, Immaculada
AU  - Sanchez-Guerrero I
FAU - Muro, Manuel
AU  - Muro M
FAU - Villar, Luisa Maria
AU  - Villar LM
FAU - Minguela, Alfredo
AU  - Minguela A
FAU - Marin, Luis
AU  - Marin L
FAU - Moya-Quiles, Maria Rosa
AU  - Moya-Quiles MR
FAU - Montes-Ares, Olga
AU  - Montes-Ares O
FAU - Pagan, Juan
AU  - Pagan J
FAU - Alvarez-Lopez, Maria Rocio
AU  - Alvarez-Lopez MR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Allergens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Alleles
MH  - Allergens/*immunology
MH  - Artemisia/*immunology
MH  - Asthma/blood/genetics/*immunology
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Skin Tests
MH  - Spain
EDAT- 2003/07/25 05:00
MHDA- 2004/03/16 05:00
CRDT- 2003/07/25 05:00
PHST- 2003/07/25 05:00 [pubmed]
PHST- 2004/03/16 05:00 [medline]
PHST- 2003/07/25 05:00 [entrez]
AID - S0198885903001095 [pii]
AID - 10.1016/s0198-8859(03)00109-5 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Aug;64(8):811-5. doi: 10.1016/s0198-8859(03)00109-5.