PMID- 12879095
OWN - NLM
STAT- MEDLINE
DCOM- 20031218
LR  - 20220330
IS  - 0954-3007 (Print)
IS  - 0954-3007 (Linking)
VI  - 57
IP  - 8
DP  - 2003 Aug
TI  - Oxidative stress status in patients with diabetes mellitus: relationship to diet.
PG  - 999-1008
AB  - OBJECTIVE: To investigate the relationship between dietary intakes and in vivo 
      oxidative stress (OS) status in diabetic patients. DESIGN: Case-control study. 
      SETTING: Outpatient-Clinic and Laboratory Endocrinology, University Antwerp. 
      SUBJECTS AND METHODS: A total of 30 patients (24 type 1 diabetes mellitus 
      (T1DM)/6 type 2 diabetes mellitus (T2DM) were asked to complete a 2 weekdays+1 
      weekend day food consumption questionnaire during the week preceding their yearly 
      diabetes control consultation, when samples were collected for the assay of 
      oxidative stress (OS) (blood levels of antioxidants, peroxides, malondialdehyde 
      (MDA) and minerals). Blood samples were also collected from 25 age- and 
      sex-matched healthy controls. RESULTS: Diabetic patients had lower glutathione 
      (5.80+/-1.15 vs 6.75+/-1.03 micromol/g Hb in the controls, P=0.002) and higher 
      MDA (0.687+/-0.212 vs 0.545+/-0.101 micromol/l, P=0.002). Although the group 
      average intakes were within the Belgian RDA, intakes of fat >35% energy, fibre 
      <15 g/1000 kcal, fruit <2 portions and vitamin E <10 mg/day were seen in more 
      than 20 patients. Blood antioxidants did not correlate with intakes of energy, 
      fat, protein or fibres or of their respective antioxidant. Vitamins A and E 
      correlated with serum lipids (r=0.58, P <0.0005 between serum alpha-tocopherol 
      and cholesterol). Blood peroxide levels were only related to intakes of saturated 
      fat and cholesterol (P<0.05). In diabetic subjects but not in controls (P<0.05) 
      MDA was related to glutathione and uric acid. CONCLUSIONS: In diabetic patients, 
      blood levels of antioxidants are not related to their dietary intakes but to 
      serum lipids. Levels of oxidative damage products are only related to intakes of 
      saturated fats and cholesterol and to levels of endogenous antioxidants.
FAU - Dierckx, N
AU  - Dierckx N
AD  - Laboratory of Endocrinology, University of Antwerp, Belgium.
FAU - Horvath, G
AU  - Horvath G
FAU - van Gils, C
AU  - van Gils C
FAU - Vertommen, J
AU  - Vertommen J
FAU - van de Vliet, J
AU  - van de Vliet J
FAU - De Leeuw, I
AU  - De Leeuw I
FAU - Manuel-y-Keenoy, B
AU  - Manuel-y-Keenoy B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 0 (Antioxidants)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antioxidants/administration & dosage/*metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 1/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - *Diet
MH  - Diet Records
MH  - Female
MH  - Glutathione/blood
MH  - Humans
MH  - Lipid Peroxidation
MH  - Male
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Oxidative Stress/*physiology
EDAT- 2003/07/25 05:00
MHDA- 2003/12/19 05:00
CRDT- 2003/07/25 05:00
PHST- 2003/07/25 05:00 [pubmed]
PHST- 2003/12/19 05:00 [medline]
PHST- 2003/07/25 05:00 [entrez]
AID - 1601635 [pii]
AID - 10.1038/sj.ejcn.1601635 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2003 Aug;57(8):999-1008. doi: 10.1038/sj.ejcn.1601635.