PMID- 12879129 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20031107 LR - 20191107 IS - 0214-0934 (Print) IS - 0214-0934 (Linking) VI - 13 IP - 10 DP - 2000 Dec TI - The dendritic cell advantage: New focus for immune-based therapies. PG - 581-6 AB - Dendritic cells (DCs) provide a much earlier and antigen-specific means for manipulating the immune response. The best-studied function of DCs is to convert antigens into immunogens for T cells. The "DC advantage" entails a myriad of functions. DCs are more than antigen-presenting cells; they are accessories or adjuvants or catalysts for triggering and controlling immunity. Another special feature of DCs is their location and movement in the body; DCs are stationed at surfaces where antigens gain access to the body. The events that make up the life history of DCs are now being unraveled in molecular terms. As research on DCs expands, more potential functions and more sites for their manipulation are becoming apparent. FAU - Steinman, R M AU - Steinman RM AD - Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10021-6399, USA. LA - eng PT - Journal Article PL - United States TA - Drug News Perspect JT - Drug news & perspectives JID - 8809164 EDAT- 2003/07/25 05:00 MHDA- 2003/07/25 05:01 CRDT- 2003/07/25 05:00 PHST- 2003/07/25 05:00 [pubmed] PHST- 2003/07/25 05:01 [medline] PHST- 2003/07/25 05:00 [entrez] AID - 207 [pii] AID - 10.1358/dnp.2000.13.10.858448 [doi] PST - ppublish SO - Drug News Perspect. 2000 Dec;13(10):581-6. doi: 10.1358/dnp.2000.13.10.858448.