PMID- 12880834
OWN - NLM
STAT- MEDLINE
DCOM- 20030909
LR  - 20220408
IS  - 1053-8119 (Print)
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 19
IP  - 3
DP  - 2003 Jul
TI  - Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a 
      decision-making task.
PG  - 1085-94
AB  - Cocaine abusers demonstrate faulty decision-making as manifested by their 
      inability to discontinue self-destructive drug-seeking behaviors. The 
      orbitofrontal cortex (OFC) plays an important role in decision-making. In this 
      preliminary study we tested whether 25-day-abstinent cocaine abusers show 
      alterations in normalized cerebral blood flow (rCBF) in the OFC using PET with 
      (15)O during the Iowa Gambling Task (a decision-making task). This task measures 
      the ability to weigh short-term rewards against long-term losses. A control task 
      matched the sensorimotor aspects of the task but did not require decision-making. 
      Cocaine abusers (N = 13) showed greater activation during performance of the Iowa 
      Gambling Task in the right OFC and less activation in the right dorsolateral 
      prefrontal cortex (DLPFC) and left medial prefrontal cortex (MPFC) compared to a 
      control group (N = 13). Better Iowa Gambling Task performance was associated with 
      greater activation in the right OFC in both groups. Also, the amount of cocaine 
      used (grams/week) prior to the 25 days of enforced abstinence was negatively 
      correlated with activation in the left OFC. Greater activation in the OFC in 
      cocaine abusers compared to a control group may reflect differences in the 
      anticipation of reward while less activation in the DLPFC and MPFC may reflect 
      differences in planning and working memory. These findings suggest that cocaine 
      abusers show persistent functional abnormalities in prefrontal neural networks 
      involved in decision-making and these effects are related to cocaine abuse. 
      Compromised decision-making could contribute to the development of addiction and 
      undermine attempts at abstinence.
FAU - Bolla, K I
AU  - Bolla KI
AD  - Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, 
      MD, USA. kbolla@jhmi.edu
FAU - Eldreth, D A
AU  - Eldreth DA
FAU - London, E D
AU  - London ED
FAU - Kiehl, K A
AU  - Kiehl KA
FAU - Mouratidis, M
AU  - Mouratidis M
FAU - Contoreggi, C
AU  - Contoreggi C
FAU - Matochik, J A
AU  - Matochik JA
FAU - Kurian, V
AU  - Kurian V
FAU - Cadet, J L
AU  - Cadet JL
FAU - Kimes, A S
AU  - Kimes AS
FAU - Funderburk, F R
AU  - Funderburk FR
FAU - Ernst, M
AU  - Ernst M
LA  - eng
GR  - M01 RR002719/RR/NCRR NIH HHS/United States
GR  - R01 MH085010/MH/NIMH NIH HHS/United States
GR  - M01 RR02719/RR/NCRR NIH HHS/United States
GR  - R01 DA011426-02/DA/NIDA NIH HHS/United States
GR  - DA 11426/DA/NIDA NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Cerebrovascular Circulation
MH  - Cocaine-Related Disorders/diagnostic imaging/*physiopathology
MH  - Decision Making/*physiology
MH  - Female
MH  - Frontal Lobe/blood supply/diagnostic imaging/*physiopathology
MH  - Gambling/psychology
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Prefrontal Cortex/blood supply/diagnostic imaging/physiopathology
MH  - Psychomotor Performance/physiology
MH  - Tomography, Emission-Computed
PMC - PMC2767245
MID - NIHMS151692
EDAT- 2003/07/26 05:00
MHDA- 2003/09/10 05:00
PMCR- 2009/10/26
CRDT- 2003/07/26 05:00
PHST- 2003/07/26 05:00 [pubmed]
PHST- 2003/09/10 05:00 [medline]
PHST- 2003/07/26 05:00 [entrez]
PHST- 2009/10/26 00:00 [pmc-release]
AID - S1053811903001137 [pii]
AID - 10.1016/s1053-8119(03)00113-7 [doi]
PST - ppublish
SO  - Neuroimage. 2003 Jul;19(3):1085-94. doi: 10.1016/s1053-8119(03)00113-7.