PMID- 12884287
OWN - NLM
STAT- MEDLINE
DCOM- 20030929
LR  - 20171116
IS  - 0014-2980 (Print)
IS  - 0014-2980 (Linking)
VI  - 33
IP  - 8
DP  - 2003 Aug
TI  - 4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through 
      changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor 
      p27kip1.
PG  - 2133-41
AB  - The T cell costimulatory receptor 4-1BB enhances cell cycle progression and 
      proliferation of CD8(+) T cells in both an IL-2-dependent and -independent 
      manner. In these studies, 4-1BB costimulation was shown to increase cyclin D2, 
      D3, and E expression, and concomitantly down-regulate the expression of the 
      cyclin-dependent kinase inhibitor p27(kip1). 4-1BB increases cyclin D2 
      transcription via mitogen-activated/extracellular signal-regulated kinase-1/2 and 
      LY294002-sensitive phosphatidylinositol 3-kinase (PI3K) signaling pathways. In 
      addition, 4-1BB up-regulates cyclin D2 translation via PI3K/Akt/mammalian target 
      of rapamycin (mTOR) pathways, presumably triggered by IL-2/IL-2 receptor 
      ligation. The enhanced cyclin D2 and D3 expression initiates up-regulation of 
      cyclin E expression and down-regulation of p27(kip1). Our results suggest a role 
      for cyclin D2, D3, and E, and p27(kip1) proteins in the 4-1BB-mediated cell cycle 
      progression of CD8(+) T cells in vivo.
FAU - Lee, Hyeon-Woo
AU  - Lee HW
AD  - Immunomodulation Research Center, University of Ulsan, Ulsan, Korea.
FAU - Nam, Kyung-Ok
AU  - Nam KO
FAU - Park, Su-Jung
AU  - Park SJ
FAU - Kwon, Byoung S
AU  - Kwon BS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens, CD)
RN  - 0 (Ccnd2 protein, mouse)
RN  - 0 (Ccnd3 protein, mouse)
RN  - 0 (Cdkn1b protein, mouse)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Cyclin D2)
RN  - 0 (Cyclin D3)
RN  - 0 (Cyclin E)
RN  - 0 (Cyclins)
RN  - 0 (Interleukin-2)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tnfrsf9 protein, mouse)
RN  - 0 (Tumor Necrosis Factor Receptor Superfamily, Member 9)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 147604-94-2 (Cyclin-Dependent Kinase Inhibitor p27)
SB  - IM
MH  - Animals
MH  - Antigens, CD
MH  - CD8-Positive T-Lymphocytes/*cytology/*physiology
MH  - Cell Cycle
MH  - Cell Cycle Proteins/*genetics
MH  - Cell Division
MH  - Cross-Linking Reagents
MH  - Cyclin D2
MH  - Cyclin D3
MH  - Cyclin E/genetics
MH  - Cyclin-Dependent Kinase Inhibitor p27
MH  - Cyclins/*genetics
MH  - Gene Expression
MH  - In Vitro Techniques
MH  - Interleukin-2/pharmacology
MH  - MAP Kinase Signaling System
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Nerve Growth Factor/*physiology
MH  - Receptors, Tumor Necrosis Factor/*physiology
MH  - Tumor Necrosis Factor Receptor Superfamily, Member 9
MH  - Tumor Suppressor Proteins/*genetics
EDAT- 2003/07/29 05:00
MHDA- 2003/09/30 05:00
CRDT- 2003/07/29 05:00
PHST- 2003/07/29 05:00 [pubmed]
PHST- 2003/09/30 05:00 [medline]
PHST- 2003/07/29 05:00 [entrez]
AID - 10.1002/eji.200323996 [doi]
PST - ppublish
SO  - Eur J Immunol. 2003 Aug;33(8):2133-41. doi: 10.1002/eji.200323996.